ID   INT11_CHICK             Reviewed;         600 AA.
AC   Q5ZIH0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Integrator complex subunit 11;
DE            Short=Int11;
DE            EC=3.1.27.-;
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein;
DE            Short=CPSF3-like protein;
GN   Name=INTS11; Synonyms=CPSF3L; ORFNames=RCJMB04_26e19;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250|UniProtKB:Q9VAH9}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ720814; CAG32473.1; -; mRNA.
DR   RefSeq; NP_001012854.1; NM_001012836.1.
DR   AlphaFoldDB; Q5ZIH0; -.
DR   SMR; Q5ZIH0; -.
DR   STRING; 9031.ENSGALP00000002583; -.
DR   PaxDb; Q5ZIH0; -.
DR   GeneID; 419418; -.
DR   KEGG; gga:419418; -.
DR   CTD; 54973; -.
DR   VEuPathDB; HostDB:geneid_419418; -.
DR   eggNOG; KOG1136; Eukaryota.
DR   InParanoid; Q5ZIH0; -.
DR   OrthoDB; 218195at2759; -.
DR   PhylomeDB; Q5ZIH0; -.
DR   PRO; PR:Q5ZIH0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0032039; C:integrator complex; ISS:HGNC.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016180; P:snRNA processing; ISS:HGNC.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..600
FT                   /note="Integrator complex subunit 11"
FT                   /id="PRO_0000259567"
FT   MOTIF           68..73
FT                   /note="HXHXDH motif"
SQ   SEQUENCE   600 AA;  68188 MW;  F5DC20FC61999BC7 CRC64;
     MPEIKVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGYN DDRRFPDFSY ITQNGRLTDF
     LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTKAIC PILLEDYRKI TVDKKGETNF
     FTSQMIKDCM KKVVAVHLHQ TVQVDEELEI KAYYAGHVLG AAMFQIKVGC ESVVYTGDYN
     MTPDRHLGAA WIDKCRPDLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
     ALGRAQELCI LLETFWERMN LKAPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
     EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG
     HKILSGQRKL EMEGRQILEV KMQVEYMSFS AHADAKGIMQ LIRQAEPRNV LLVHGEAKKM
     EFLKQKIEQE FHVNCYMPAN GETTTIFTNP SIPVDISLGL LKRETAIGLL PDAKKPKLMH
     GTLIMKDNSF RLVSPEQALK ELGLAEHQLR FTCRVHIQDP RKEHETVLRV YNHLKGVLKD
     YSVQHLPDGS ITVESILIQA TAHSEDQGTK VLLVSWTYQD EELGSYLTSL LKKGLPQSTS