ID   INT11_DANRE             Reviewed;         598 AA.
AC   Q503E1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Integrator complex subunit 11;
DE            Short=Int11;
DE            EC=3.1.27.-;
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein;
DE            Short=CPSF3-like protein;
GN   Name=cpsf3l; Synonyms=ints11; ORFNames=zgc:110671;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250|UniProtKB:Q9VAH9}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC095364; AAH95364.1; -; mRNA.
DR   RefSeq; NP_001018457.1; NM_001020621.1.
DR   AlphaFoldDB; Q503E1; -.
DR   SMR; Q503E1; -.
DR   STRING; 7955.ENSDARP00000093676; -.
DR   PaxDb; Q503E1; -.
DR   GeneID; 553648; -.
DR   KEGG; dre:553648; -.
DR   CTD; 54973; -.
DR   ZFIN; ZDB-GENE-050522-13; ints11.
DR   eggNOG; KOG1136; Eukaryota.
DR   InParanoid; Q503E1; -.
DR   PhylomeDB; Q503E1; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q503E1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; IMP:ZFIN.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..598
FT                   /note="Integrator complex subunit 11"
FT                   /id="PRO_0000259568"
FT   MOTIF           68..73
FT                   /note="HXHXDH motif"
SQ   SEQUENCE   598 AA;  67592 MW;  AEB66E60A346B396 CRC64;
     MPDIKVTPLG AGQDVGRSCI LVSIGGKNIM LDCGMHMGFN DDRRFPDFSY ITQNGRLTEF
     LDCVIISHFH LDHCGALPYM SEMVGYDGPI YMTHPTKAIC PILLEDFRKI TVDKKGETNF
     FTSQMIKDCM KKVVPLNLHQ TVQVDDELEI KAYYAGHVLG AAMVQIKVGS ESVVYTGDYN
     MTPDRHLGAA WIDKCRPDIL ISESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
     ALGRAQELCI LLETFWERMN LKAPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
     EFKHIKAFDR SYADNPGPMV VFATPGMLHA GQSLQIFKKW AGNEKNMVIM PGYCVQGTVG
     HKILNGQKKL EMEGRATLDV KLQVEYMSFS AHADAKGIMQ LIRMAEPRNM LLVHGEAKKM
     EFLKDKIEQE FSISCFMPAN GETTTIVTNP SVPVDISLNL LKREMALGGP LPDAKRPRTM
     HGTLIMKDNS LRLVSPEQAL KELGLNEHQL RFTCRVQLHD PHSDTDTLSR IYTHLKSVLK
     SYSIQHVPDG TVIVESIVIK VTSSAEEPNL KVILLSWSYQ DEELGSFLST LLKKGLPS