ID   INT11_DICDI             Reviewed;         744 AA.
AC   Q54YL3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Integrator complex subunit 11 homolog;
DE            EC=3.1.27.-;
GN   Name=ints11; ORFNames=DDB_G0278189;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000023; EAL68267.1; -; Genomic_DNA.
DR   RefSeq; XP_642189.1; XM_637097.1.
DR   AlphaFoldDB; Q54YL3; -.
DR   SMR; Q54YL3; -.
DR   STRING; 44689.DDB0234100; -.
DR   PaxDb; Q54YL3; -.
DR   EnsemblProtists; EAL68267; EAL68267; DDB_G0278189.
DR   GeneID; 8621396; -.
DR   KEGG; ddi:DDB_G0278189; -.
DR   dictyBase; DDB_G0278189; ints11.
DR   eggNOG; KOG1136; Eukaryota.
DR   HOGENOM; CLU_009673_3_1_1; -.
DR   InParanoid; Q54YL3; -.
DR   OMA; EYWREHE; -.
DR   PhylomeDB; Q54YL3; -.
DR   PRO; PR:Q54YL3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..744
FT                   /note="Integrator complex subunit 11 homolog"
FT                   /id="PRO_0000344382"
FT   REGION          626..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           67..72
FT                   /note="HXHXDH motif"
SQ   SEQUENCE   744 AA;  84350 MW;  9ED4F29AE958DB7D CRC64;
     MTIKVVPLGA GQDVGRSCVI VTIGNKNIMF DCGMHMGMND ARRFPDFSYI SKNGQFTKVI
     DCVIITHFHL DHCGALPFFT EMCGYDGPIY MTLPTKAICP ILLEDYRKIT VEKKGETNFF
     TAQMIKDCMK KVIPVNLHQT IKVDEELSIK AYYAGHVLGA AMFYAKVGDE SVVYTGDYNM
     TPDRHLGSAW IDQVKPDVLI TETTYATTIR DSKRGRERDF LKRIHECVEK GGKVLIPVFA
     LGRVQELCIL IDSYWEQMNL GHIPIYFSAG LAEKANLYYK LFINWTNQKI KQTFVKRNMF
     DFKHIKPFQS HLVDAPGAMV LFATPGMLHA GASLEVFKKW APNELNMTII PGYCVVGTVG
     NKLLTTGSDQ QQQSKPQSQM VEIDKKTTIE VKCKIHNLSF SAHADAKGIL QLIKMSNPRN
     VILVHGEKEK MGFLSQKIIK EMGVNCYYPA NGVTIIIDTM KSIPIDISLN LLKRQILDYS
     YQYNNNNLNN FNNFNNLNNL NNNNNNNNNN SLKLIDIKNN TSTLFINNNN NNKKKQQSVV
     VVEESEENQD NNLIEEESFI SSNNLLKKAR LPISTIPIQG LMVSKQDQSS SSSNSNQLKL
     LGMNEVSKEL SIKEIEMQYS LNLNFNNNTS DDNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     NNNNNNNNND NISLNFEFLT NELQRLLPIG INIERLEDSF FKPISLKIKS VSIQHISNMN
     IVVKWLHKDE NLATHIISIL KSIN