ID   INT11_PONAB             Reviewed;         600 AA.
AC   Q5NVE6; Q5NVC5; Q5REX8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Integrator complex subunit 11;
DE            Short=Int11;
DE            EC=3.1.27.-;
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein;
DE            Short=CPSF3-like protein;
GN   Name=INTS11; Synonyms=CPSF3L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. The Integrator complex is
CC       associated with the C-terminal domain (CTD) of RNA polymerase II
CC       largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC       genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of
CC       cytoplasmic dynein to the nuclear envelope, probably as component of
CC       the INT complex. {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250|UniProtKB:Q9VAH9}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH89679.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR857385; CAH89679.1; ALT_SEQ; mRNA.
DR   EMBL; CR926091; CAI29717.1; -; mRNA.
DR   EMBL; CR926113; CAI29738.1; -; mRNA.
DR   RefSeq; NP_001124760.1; NM_001131288.1.
DR   RefSeq; NP_001128922.1; NM_001135450.1.
DR   AlphaFoldDB; Q5NVE6; -.
DR   SMR; Q5NVE6; -.
DR   STRING; 9601.ENSPPYP00000002328; -.
DR   Ensembl; ENSPPYT00000002399; ENSPPYP00000002328; ENSPPYG00000002013.
DR   GeneID; 100171611; -.
DR   GeneID; 100189874; -.
DR   KEGG; pon:100171611; -.
DR   CTD; 54973; -.
DR   eggNOG; KOG1136; Eukaryota.
DR   GeneTree; ENSGT00940000157644; -.
DR   InParanoid; Q5NVE6; -.
DR   OrthoDB; 218195at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..600
FT                   /note="Integrator complex subunit 11"
FT                   /id="PRO_0000259565"
FT   MOTIF           68..73
FT                   /note="HXHXDH motif"
FT   CONFLICT        92
FT                   /note="M -> V (in Ref. 1; CAI29738)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        203
FT                   /note="E -> G (in Ref. 1; CAI29738)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        294
FT                   /note="F -> S (in Ref. 1; CAI29717)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        313
FT                   /note="A -> T (in Ref. 1; CAH89679)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        423
FT                   /note="L -> Q (in Ref. 1; CAH89679)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   600 AA;  67664 MW;  7D1EECCEA1E13061 CRC64;
     MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF
     LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF
     FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN
     MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
     ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF
     EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG
     HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM
     EFLKQKIEQE LRVSCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PEAKKPRLLH
     GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSILKD
     HCVQHLPDGS VTVESILIQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS