ID   INT11_RAT               Reviewed;         600 AA.
AC   Q3MHC2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Integrator complex subunit 11;
DE            Short=Int11;
DE            EC=3.1.27.-;
DE   AltName: Full=Cleavage and polyadenylation-specific factor 3-like protein;
DE            Short=CPSF3-like protein;
GN   Name=Ints11; Synonyms=Cpsf3l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Catalytic component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. The Integrator complex is
CC       associated with the C-terminal domain (CTD) of RNA polymerase II
CC       largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC       genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of
CC       cytoplasmic dynein to the nuclear envelope, probably as component of
CC       the INT complex. {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5TA45}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5TA45}.
CC   -!- DOMAIN: The HXHXDH motif is essential for the endoribonuclease activity
CC       of the CPSF complex. {ECO:0000250|UniProtKB:Q9VAH9}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC105303; AAI05304.1; -; mRNA.
DR   RefSeq; NP_001029064.2; NM_001033892.2.
DR   AlphaFoldDB; Q3MHC2; -.
DR   SMR; Q3MHC2; -.
DR   STRING; 10116.ENSRNOP00000026725; -.
DR   PaxDb; Q3MHC2; -.
DR   PRIDE; Q3MHC2; -.
DR   GeneID; 298688; -.
DR   KEGG; rno:298688; -.
DR   CTD; 54973; -.
DR   RGD; 1306841; Ints11.
DR   VEuPathDB; HostDB:ENSRNOG00000019712; -.
DR   eggNOG; KOG1136; Eukaryota.
DR   HOGENOM; CLU_009673_3_2_1; -.
DR   InParanoid; Q3MHC2; -.
DR   OMA; YLDGMIW; -.
DR   OrthoDB; 218195at2759; -.
DR   PhylomeDB; Q3MHC2; -.
DR   TreeFam; TF105878; -.
DR   Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q3MHC2; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000019712; Expressed in testis and 19 other tissues.
DR   Genevisible; Q3MHC2; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032039; C:integrator complex; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004521; F:endoribonuclease activity; ISO:RGD.
DR   GO; GO:0016180; P:snRNA processing; ISO:RGD.
DR   CDD; cd16291; INTS11-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR041897; INTS11-like_MBL-fold.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Nucleus; Reference proteome.
FT   CHAIN           1..600
FT                   /note="Integrator complex subunit 11"
FT                   /id="PRO_0000259566"
FT   MOTIF           68..73
FT                   /note="HXHXDH motif"
SQ   SEQUENCE   600 AA;  67841 MW;  20E48D38DC3640B3 CRC64;
     MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY ITQSGRLTDF
     LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF
     FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN
     MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF
     ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
     EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG
     HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM
     EFLRQKIEQE FRVSCYMPAN GETVTLPTSP SIPVGISLGL LKREMVQGLL PEAKKPRLLH
     GTLIMKDNNF RLVSSEQALK ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD
     HCVQHLPDGS VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTAL LKNGLPQAPS