ID   INT12_DANRE             Reviewed;         479 AA.
AC   Q6IQU7; Q4V9A0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Integrator complex subunit 12;
DE            Short=Int12;
GN   Name=ints12; ORFNames=zgc:86602;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 12 family. {ECO:0000305}.
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DR   EMBL; BC096989; AAH96989.1; -; mRNA.
DR   EMBL; BC071306; AAH71306.1; -; mRNA.
DR   RefSeq; NP_001002161.2; NM_001002161.3.
DR   AlphaFoldDB; Q6IQU7; -.
DR   SMR; Q6IQU7; -.
DR   STRING; 7955.ENSDARP00000106610; -.
DR   PaxDb; Q6IQU7; -.
DR   Ensembl; ENSDART00000125690; ENSDARP00000106610; ENSDARG00000091678.
DR   GeneID; 415251; -.
DR   KEGG; dre:415251; -.
DR   CTD; 57117; -.
DR   ZFIN; ZDB-GENE-040625-178; ints12.
DR   eggNOG; KOG4323; Eukaryota.
DR   GeneTree; ENSGT00390000005218; -.
DR   HOGENOM; CLU_033336_0_0_1; -.
DR   InParanoid; Q6IQU7; -.
DR   OMA; AKQDKRN; -.
DR   OrthoDB; 1631937at2759; -.
DR   PhylomeDB; Q6IQU7; -.
DR   TreeFam; TF106418; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q6IQU7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000091678; Expressed in ovary and 28 other tissues.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   CDD; cd15501; PHD_Int12; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039053; Int12.
DR   InterPro; IPR039054; Int12_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13415:SF4; PTHR13415:SF4; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..479
FT                   /note="Integrator complex subunit 12"
FT                   /id="PRO_0000259570"
FT   ZN_FING         161..217
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          57..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        77
FT                   /note="A -> V (in Ref. 1; AAH96989)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        84
FT                   /note="T -> S (in Ref. 1; AAH96989)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        85
FT                   /note="S -> N (in Ref. 1; AAH96989)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="T -> I (in Ref. 1; AAH96989)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   479 AA;  49591 MW;  1E42A2E96C36FCB4 CRC64;
     MAGTVSLELD PIFLKGLGYL HSKSKDSAEK LKALLDESLA RGSDSIYRNS IKEAEVSKVS
     LPKMTKQDSK SSSSSSASSS ITTTSSSKSS TSEKSKKESE KRTLEKIRVD PGEGVEPPKK
     PRLEKQDSHS SPIAFQTKDI PIPDFTDIDE TNADDFAMEM GLACVVCRQM TVTSGNQLVE
     CQECHNLYHQ ECHKPQVTDK DVNDPRLVWY CARCTRQMKR MAQKTQKPPQ KPAPALATTV
     PLLKDPLVKK AELKPKPETT GSFQAFKRTE VKATAASGNS SSSSSSSSSL PPGLTGWAAF
     TKATSNVGPS STKLSTSQSG NSKTSPAASG SKPVGLSALA NVKPALATKP SGGSSAGSGN
     GNNGSGTVPL KAPPPLTLGK QVLSRSASGD SLGKMTVTGS LSPGAAPSSS LGGNGGSGGN
     GAGNGGNSAG SSSSSGNNNN NGAKASADGK APTSQESQLN AMKRLQMVKK KAAQKKLKK