ID   INT12_XENLA             Reviewed;         464 AA.
AC   Q6DJM6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Integrator complex subunit 12;
DE            Short=Int12;
GN   Name=ints12;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 12 family. {ECO:0000305}.
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DR   EMBL; BC075149; AAH75149.1; -; mRNA.
DR   RefSeq; NP_001086353.1; NM_001092884.1.
DR   RefSeq; XP_018092689.1; XM_018237200.1.
DR   RefSeq; XP_018092694.1; XM_018237205.1.
DR   AlphaFoldDB; Q6DJM6; -.
DR   SMR; Q6DJM6; -.
DR   DNASU; 444782; -.
DR   GeneID; 444782; -.
DR   KEGG; xla:444782; -.
DR   CTD; 444782; -.
DR   Xenbase; XB-GENE-977208; ints12.S.
DR   OMA; AKQDKRN; -.
DR   OrthoDB; 1631937at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 444782; Expressed in testis and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   CDD; cd15501; PHD_Int12; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039053; Int12.
DR   InterPro; IPR039054; Int12_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13415:SF4; PTHR13415:SF4; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..464
FT                   /note="Integrator complex subunit 12"
FT                   /id="PRO_0000259571"
FT   ZN_FING         156..212
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          42..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..445
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  48913 MW;  A47390D63B41DD6E CRC64;
     MAVTINTELD PVFLKALGYL HSKSKDSAEK LKALLDESLC KGNDSVYRPQ PKEVEQPKAM
     LSKVKPETKA SSSTPSSSIL SKPLASEKVK KEAEKRTADK MKVEINDIMD IPKKPRIEKT
     EARSSPVTVQ LSKDLPVPDL SSFEETSADD FAMEMGLACV VCRQMTVFSG NQLVECQECH
     NLYHQDCHRP QVTDKDVNDP RLVWYCARCT RQMKRMAQKN QKPSQKPAPS AVSAVTPVAK
     DPSVNKPELK SKSDSANTFL AFKRAEVKAS SAVSSNPSNS GVSSSSASGL TGWAAFGAKT
     ASAVPVSGKL GTNSQATSGK PPSLSSVQKA GTVPGLTPSK AGSVSKSGSG GSSSTIPLKP
     LPPLILGKTG LSRSMSSDNV SKTGLPSPNP SSSGSVSSLS SQLGSNNGSS NTAGSNVNSS
     NKVAVDPSMQ QSGAKGPTSQ ESQLNAMKRL QMVKKKAAQK KLKK