ID   INT12_XENTR             Reviewed;         466 AA.
AC   Q0V9U1;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Integrator complex subunit 12;
DE            Short=Int12;
GN   Name=ints12;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 12 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121396; AAI21397.1; -; mRNA.
DR   RefSeq; NP_001072325.1; NM_001078857.1.
DR   AlphaFoldDB; Q0V9U1; -.
DR   SMR; Q0V9U1; -.
DR   STRING; 8364.ENSXETP00000030789; -.
DR   PaxDb; Q0V9U1; -.
DR   GeneID; 779778; -.
DR   KEGG; xtr:779778; -.
DR   CTD; 57117; -.
DR   Xenbase; XB-GENE-977203; ints12.
DR   eggNOG; KOG4323; Eukaryota.
DR   InParanoid; Q0V9U1; -.
DR   OrthoDB; 1631937at2759; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   CDD; cd15501; PHD_Int12; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039053; Int12.
DR   InterPro; IPR039054; Int12_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13415:SF4; PTHR13415:SF4; 1.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..466
FT                   /note="Integrator complex subunit 12"
FT                   /id="PRO_0000259572"
FT   ZN_FING         156..212
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          41..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          311..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  48950 MW;  155A0F7A327EF875 CRC64;
     MAVTINTELD PVFLKALGYL HSKSKDSAEK LKALLDESLC KGNDSVYRPQ PKEMEQPKAM
     LSKVKPETKA SSSTPSSSML SKPLTSEKLK KEAEKRSADK MKVEISDVMD IPKKPRIEKT
     EARSSPVTVQ LSKDLPVPDL SSFDETSADD FAMEMGLACV VCRQMTVFSG NQLVECQECH
     NLYHQDCHKP QVTDKDVNDP RLVWYCARCT RQMKRMAQKN QKPSQKPSPS AVSAVTPVAK
     DPSVNKPELK AKPDSANTFL AFKRAEVKAS SAVSSSSSNS GVSSSSASGL TGWAAFGAKT
     ANAVPVLGKL GTSSQATSGK PPSLSSVQKT GAAPGLAPSK PGSVSKSGSG GSSSSSTIPI
     KPLPPLILGK TGLSRSMSSD NVSKTGLPSP NPSSAGSVSS LSSQLGSNNG SSSAAGSNVT
     SSNKVAVDPS MQLSGAKGPT SQESQLNAMK RLQMVKKKAA QKKLKK