ID   INT13_DROAN             Reviewed;         682 AA.
AC   B3LVQ1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein asunder;
DE   AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Set apart in position or space protein;
GN   Name=asun; Synonyms=Mat89Bb; ORFNames=GF16409;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000312|EMBL:EDV43675.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV43675.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC       regulator of the mitotic cell cycle and development. Required for the
CC       correct dynein-dynactin perinuclear localization important for nucleus-
CC       centrosome coupling that occur upon meiotic progression of primary
CC       spermatocytes. Crucial regulator of the mitotic cell cycle and
CC       development. Plays a role in sperm motility and fertility. May have a
CC       role in the PNG/PLU/GNU pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC       on the nuclear surface at the meiotic G2/prophase transition in primary
CC       spermatocytes. Nuclear location is required for recruitment of dynein
CC       motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR   EMBL; CH902617; EDV43675.1; -; Genomic_DNA.
DR   RefSeq; XP_001955114.1; XM_001955078.2.
DR   AlphaFoldDB; B3LVQ1; -.
DR   SMR; B3LVQ1; -.
DR   STRING; 7217.FBpp0119601; -.
DR   EnsemblMetazoa; FBtr0121109; FBpp0119601; FBgn0093430.
DR   GeneID; 6499205; -.
DR   KEGG; dan:6499205; -.
DR   eggNOG; KOG3711; Eukaryota.
DR   HOGENOM; CLU_012654_1_0_1; -.
DR   InParanoid; B3LVQ1; -.
DR   OMA; CMDEAPS; -.
DR   OrthoDB; 676663at2759; -.
DR   PhylomeDB; B3LVQ1; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 1.
DR   Pfam; PF10221; DUF2151; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW   Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..682
FT                   /note="Protein asunder"
FT                   /id="PRO_0000385339"
FT   REGION          571..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          517..570
FT                   /evidence="ECO:0000255"
FT   MOTIF           606..612
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT   COMPBIAS        594..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  74776 MW;  8F3C5167289445EB CRC64;
     MFEQNQKTIF VLDHTRYFSI ASEDYISMDF LKGKPSVDTG TGAGVGGASG LGTQFSKSLW
     TCACESSIEY CRVVWDLFPG KKHVRFIVSD TAAHIVNTWS TSTQNMSHVM NAMVMVGVPS
     RSMPQSSDYS VIHGLRAAIE ALAEPTDEQL ATIASGEPVH IPNEGRVICI TSARDNTSMK
     SLEDIFNTVL IQQNALAGPP AKKGLAIDHC HLVILNIVPL GVESLVTNRG LLNISPLLDV
     EIHTVSAPDI SHKLTHLILD HYNLASTTVT NIPMKEEQNA NSSANYDVEI LHSRSAHSIA
     CGPDFSLPTS IKPGATYETV TLKWCTPRGC GSADLQPCLG QFLVTPVDVT SRPSSCLINF
     LLNGRSVLLE MPRKAGSKAT SHMLSARGGE IFIHSLCITR SCMDEAPAIG DGPGGRVTDY
     RTTELGQLMK MSRMVPLKAK DPTAPGLPRR MPRYFPLTNG SSILFHLQRH ISWMPHFLHL
     LVKEDMDKQE EVRCQQHIHE LYKSASRGDM LPFTHTNGAR LKLSKAKDQY RLLYRELEQL
     IHLNATTVHH KNLLESLQSL RAAYGEAKSE PNSSLLRSYT ESPHSPERLE PIPSGGSSGS
     NSNSLLKASK RRMSSCGQRS LLDIISSAER SQANKRLDFS GRLCTPLGQV AKLYPDFGNK
     EKDSLLAGTT AAPNVKEESI RS