INT13_DROGR
ID INT13_DROGR Reviewed; 678 AA.
AC B4JHB4;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Protein asunder;
DE AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE AltName: Full=Set apart in position or space protein;
GN Name=asun; Synonyms=Mat89Bb; ORFNames=GH19540;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDV93821.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV93821.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC regulator of the mitotic cell cycle and development. Required for the
CC correct dynein-dynactin perinuclear localization important for nucleus-
CC centrosome coupling that occur upon meiotic progression of primary
CC spermatocytes. Crucial regulator of the mitotic cell cycle and
CC development. Plays a role in sperm motility and fertility. May have a
CC role in the PNG/PLU/GNU pathway (By similarity).
CC {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC on the nuclear surface at the meiotic G2/prophase transition in primary
CC spermatocytes. Nuclear location is required for recruitment of dynein
CC motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH916369; EDV93821.1; -; Genomic_DNA.
DR RefSeq; XP_001990759.1; XM_001990723.1.
DR AlphaFoldDB; B4JHB4; -.
DR SMR; B4JHB4; -.
DR STRING; 7222.FBpp0153446; -.
DR EnsemblMetazoa; FBtr0154954; FBpp0153446; FBgn0127005.
DR GeneID; 6564276; -.
DR KEGG; dgr:6564276; -.
DR eggNOG; KOG3711; Eukaryota.
DR HOGENOM; CLU_012654_1_0_1; -.
DR InParanoid; B4JHB4; -.
DR OMA; XPVSLLS; -.
DR OrthoDB; 676663at2759; -.
DR PhylomeDB; B4JHB4; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR PANTHER; PTHR12955; PTHR12955; 2.
DR Pfam; PF10221; DUF2151; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..678
FT /note="Protein asunder"
FT /id="PRO_0000385341"
FT REGION 570..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 603..609
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT COMPBIAS 586..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 75419 MW; FE135AC5227114C7 CRC64;
MFERNEKTIF VLDHTRYFSI SSEQYISMDY LKGKPMPAET PAAGSSVGTQ LSKSLWTCAV
ESSIEYCRIV WDLFPGRKHV RFIVSDTAAH IVNTWSPSTQ NMSHVSNAMM MVSVPSRSIP
QSSDYSVIHG LRAAIEALAE PTDEQLQAAQ VGCKKISNEG RVICITSARD NTSMKSLEDI
FNTVLLQQNA LVGPPGKKGL SIDHCHLVIL NIVPLGVESL VTNRSLLEIS PLLDVEIHTV
HAPNISDKLL HLIMGHYDLA STTVTNIPMK EEQNANSSAN YDVEILHARA AHTKVCGPDF
TLTTSIKPGT SYETVTLKWC TPRGCGSSDL QPCVGQYNVT PVDVTSRPSS CLINFLLNGR
SVLLEVPRKT GTKTTSHMLS ARGGEIFVHS LSIARSAMDE APSITDGPGG RVADYRIPEL
GQLLKMSRMV PLKAKPKGKM SQGEHLWRRL PRYFPRTMNV TILFNLQRQL SWLPHFLHLL
VKEDMDKQDE VRCQQQIHEL YKSASRGDML PFTNTNNTRP KMSKTKDQYR LFYRELEQLI
QLNVQTVHHK NLLESLQSLR AAYGDVTNKS EPGAAHLRSY TESPLSPERL EPNSTSSSSN
SLLKASKRRM SSSGQRSLLD MISSAERSQS SKRLDFTGRL CTPIGQTAKL YPDFGNKDKD
ILTPGVIPSN LKDDSIRS
