INT13_DROMO
ID INT13_DROMO Reviewed; 679 AA.
AC B4K5S8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Protein asunder;
DE AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE AltName: Full=Set apart in position or space protein;
GN Name=asun; Synonyms=Mat89Bb; ORFNames=GI22939;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1] {ECO:0000312|EMBL:EDW15140.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW15140.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC regulator of the mitotic cell cycle and development. Required for the
CC correct dynein-dynactin perinuclear localization important for nucleus-
CC centrosome coupling that occur upon meiotic progression of primary
CC spermatocytes. Crucial regulator of the mitotic cell cycle and
CC development. Plays a role in sperm motility and fertility. May have a
CC role in the PNG/PLU/GNU pathway (By similarity).
CC {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC on the nuclear surface at the meiotic G2/prophase transition in primary
CC spermatocytes. Nuclear location is required for recruitment of dynein
CC motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR EMBL; CH933806; EDW15140.1; -; Genomic_DNA.
DR RefSeq; XP_001999679.1; XM_001999643.2.
DR AlphaFoldDB; B4K5S8; -.
DR SMR; B4K5S8; -.
DR STRING; 7230.FBpp0172156; -.
DR EnsemblMetazoa; FBtr0173664; FBpp0172156; FBgn0145666.
DR GeneID; 6573613; -.
DR KEGG; dmo:Dmoj_GI22939; -.
DR eggNOG; KOG3711; Eukaryota.
DR HOGENOM; CLU_012654_1_0_1; -.
DR InParanoid; B4K5S8; -.
DR OMA; CMDEAPS; -.
DR OrthoDB; 676663at2759; -.
DR PhylomeDB; B4K5S8; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR PANTHER; PTHR12955; PTHR12955; 2.
DR Pfam; PF10221; DUF2151; 2.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..679
FT /note="Protein asunder"
FT /id="PRO_0000385343"
FT REGION 564..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 519..541
FT /evidence="ECO:0000255"
FT MOTIF 604..610
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT COMPBIAS 572..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 75410 MW; 999EF8FFC1540D92 CRC64;
MFERNQKTIF VLDHTRYFSI SSEQYISMDY LKGKPVAESP GSGSSIVGTQ LSKSLWTCAV
ESSIEYCRIV WDLFPGKKHV RFIVSDTAAH IVNTWSPSTQ NMSHVSNAMM MVSVPSRSIP
QSSDYSVIHG LRAAIEALAE PTDEQLQAAH AGCKRIGNKG RVICITSARD NTSMKSLEDI
FNTVLIQQNA LVAPPSKKGL QIDHCHLVIL NIVPLGVESL VTNRSLLEIS PFLNAEIHTV
NAPEISDKLL HLIMGHYDLA STTVTNIPMK EEQNANSSAN YDVEILHERA AHTKVCGPDF
TFTTSIKPGT AYETVTLKWC TPRGCGSADL QPCVGQYNVT PVDVTSRPSS CLINFLLNGR
SVLLEVPRKS GTKTTSHMLS ARGGEIFVHS LSIARSAMDE APSITDGPGG RVPDYRIPEM
GQLLKMSRLV PLKTRPKGKC SQGEHLWRRM PRYFPRTANA TILFNLQRQL SWLPHFLHLL
VKEDMDKQDE VRCQQQIHEL YKSASRGDLL PFSNSNNARL KVNKTKDQYR LFYRELEQLI
QLNAHTPHHK NLLESLQSLR AAYGDASNKS DPSAAHLRSY TESPLSPERL EPTNSVNSSS
SSILKASKRR MSGCGQRSLL DIISSAERSQ SSKRLDFSGR LCTPLGQTAK LYPEFGNKDK
EILTPGVIPS SLKDESIRS
