ID   INT13_DROPE             Reviewed;         674 AA.
AC   B4GFN8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Protein asunder;
DE   AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Set apart in position or space protein;
GN   Name=asun; Synonyms=Mat89Bb; ORFNames=GL21594;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1] {ECO:0000312|EMBL:EDW34423.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC       regulator of the mitotic cell cycle and development. Required for the
CC       correct dynein-dynactin perinuclear localization important for nucleus-
CC       centrosome coupling that occur upon meiotic progression of primary
CC       spermatocytes. Crucial regulator of the mitotic cell cycle and
CC       development. Plays a role in sperm motility and fertility. May have a
CC       role in the PNG/PLU/GNU pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC       on the nuclear surface at the meiotic G2/prophase transition in primary
CC       spermatocytes. Nuclear location is required for recruitment of dynein
CC       motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR   EMBL; CH479182; EDW34423.1; -; Genomic_DNA.
DR   RefSeq; XP_002017323.1; XM_002017287.1.
DR   AlphaFoldDB; B4GFN8; -.
DR   SMR; B4GFN8; -.
DR   STRING; 7234.FBpp0185701; -.
DR   EnsemblMetazoa; FBtr0187209; FBpp0185701; FBgn0159187.
DR   GeneID; 6591686; -.
DR   KEGG; dpe:6591686; -.
DR   eggNOG; KOG3711; Eukaryota.
DR   HOGENOM; CLU_012654_1_0_1; -.
DR   OMA; CMDEAPS; -.
DR   PhylomeDB; B4GFN8; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR   GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 1.
DR   Pfam; PF10221; DUF2151; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW   Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..674
FT                   /note="Protein asunder"
FT                   /id="PRO_0000385344"
FT   COILED          516..538
FT                   /evidence="ECO:0000255"
FT   MOTIF           601..607
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VEX5"
SQ   SEQUENCE   674 AA;  74316 MW;  8467DE82C71BF9A5 CRC64;
     MFERNQKTIF VLDHTRYFSI ASEEYISMDF LKGKPSAHSS AGGSSQFSKS LWTCACESSI
     EYCRVVWDLF PGKKHVRFIV SDTAAHIVNT WSASTQNMSH VMNAMVMVGV PSRSMPQSSD
     YSVIHGLRAA IEALAEPTDE QSQAMASGIP DDLILNEGRV ICITSARDNT SMKSLEDIFN
     TVLIQQNVLS ATPPKKGLGI NHCHLVILNI VPLGIDSMVT NRNLLEISPL LDVEIHTVGA
     PDISYKLTHL ILDHYDLAST TVTNIPMKEE QNANSSANYD VEILHSRRAH SITCGPDFSL
     PTSIKQGATY ETVTLKWCTP RGCGSADLQP CLGQFLVTPV DVTSRPSSCL INFLLNGRSV
     LLEMPRKTGS KATSHMLSAR GGEIFIHSLC ITRSCMDEAP SIADGPGGRV NDYRTSELGQ
     LMKMSRMVPL KSRDPAAPNL PRRLPRYFPL TTTSTVLFHL QRHLSWLPHF LHLLVKEMDK
     QDEVRCQQHI HELYKSASRG DVLPFTHTNG ARLKPHKAKD QYRLLYRELE QLIQLNASTV
     HHKNLLESLQ TLRAAYGDAP SKSEAGTVNL RSFTESPLSP ERLEAMSNVS ISSSTNSNSL
     LKASKRRMSN CGTRSLLDII SSAERSQSNK RLDFSGRICT PIGQIAKLYP DFGNKEKDAA
     AAAAASGVGV APKE