INT13_DROPS
ID INT13_DROPS Reviewed; 674 AA.
AC Q295U5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Protein asunder;
DE AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE AltName: Full=Set apart in position or space protein;
GN Name=asun; Synonyms=Mat89Bb; ORFNames=GA19879;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL28613.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC regulator of the mitotic cell cycle and development. Required for the
CC correct dynein-dynactin perinuclear localization important for nucleus-
CC centrosome coupling that occur upon meiotic progression of primary
CC spermatocytes. Crucial regulator of the mitotic cell cycle and
CC development. Plays a role in sperm motility and fertility. May have a
CC role in the PNG/PLU/GNU pathway (By similarity).
CC {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC on the nuclear surface at the meiotic G2/prophase transition in primary
CC spermatocytes. Nuclear location is required for recruitment of dynein
CC motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR EMBL; CM000070; EAL28613.1; -; Genomic_DNA.
DR RefSeq; XP_001359467.1; XM_001359430.2.
DR AlphaFoldDB; Q295U5; -.
DR SMR; Q295U5; -.
DR STRING; 7237.FBpp0281487; -.
DR EnsemblMetazoa; FBtr0283049; FBpp0281487; FBgn0079875.
DR GeneID; 4802572; -.
DR KEGG; dpo:Dpse_GA19879; -.
DR eggNOG; KOG3711; Eukaryota.
DR HOGENOM; CLU_012654_1_0_1; -.
DR InParanoid; Q295U5; -.
DR OMA; CMDEAPS; -.
DR PhylomeDB; Q295U5; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0079875; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR PANTHER; PTHR12955; PTHR12955; 1.
DR Pfam; PF10221; DUF2151; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..674
FT /note="Protein asunder"
FT /id="PRO_0000385345"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 516..538
FT /evidence="ECO:0000255"
FT MOTIF 601..607
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT COMPBIAS 565..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 674 AA; 74274 MW; 72259D33EFBD2CC4 CRC64;
MFERNQKTIF VLDHTRYFSI ASEEYISMDF LKGKPSAHSS AGGSSQFSKS LWTCACESSI
EYCRVVWDLF PGKKHVRFIV SDTAAHIVNT WSASTQNMSH VMNAMVMVGV PSRSMPQSSD
YSVIHGLRAA IEALAEPTDE QSQAMASGVP DDLILNEGRV ICITSARDNT SMKSLEDIFN
TVLIQQNVLS ATPPKKGLGI NHCHLVILNI VPLGIDSMVT NRNLLEISPL LDVEIHTVGA
PDISYKLTHL ILDHYDLAST TVTNIPMKEE QNANSSANYD VEILHSRRAH SITCGPDFSL
PTSIKQGATY ETVTLKWCTP RGCGSADLQP CLGQFLVTPV DVTSRPSSCL INFLLNGRSV
LLEMPRKTGS KATSHMLSAR GGEIFIHSLC ITRSCMDEAP SIADGPGGRV NDYRTSELGQ
LMKMSRMVPL KSRDPAAPNL PRRLPRYFPL TTTSTVLFHL QRHLSWLPHF LHLLVKEMDK
QDEVRCQQHI HELYKSASRG DVLPFTHTNG ARLKPHKAKD QYRLLYRELE QLIQLNASTV
HHKNLLESLQ TLRAAYGDAP SKSEAGTANL RSFTESPLSP ERLEAMSNVS ISSSTNSNSL
LKASKRRMSN CGTRSLLDII SSAERSQSNK RLDFSGRICT PIGQIAKLYP DFGNKEKDAA
AAAAASGVGV APKE
