ID   INT13_DROVI             Reviewed;         681 AA.
AC   B4LWT5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Protein asunder;
DE   AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Set apart in position or space protein;
GN   Name=asun; Synonyms=Mat89Bb; ORFNames=GJ23719;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:EDW66656.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW66656.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC       regulator of the mitotic cell cycle and development. Required for the
CC       correct dynein-dynactin perinuclear localization important for nucleus-
CC       centrosome coupling that occur upon meiotic progression of primary
CC       spermatocytes. Crucial regulator of the mitotic cell cycle and
CC       development. Plays a role in sperm motility and fertility. May have a
CC       role in the PNG/PLU/GNU pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC       on the nuclear surface at the meiotic G2/prophase transition in primary
CC       spermatocytes. Nuclear location is required for recruitment of dynein
CC       motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR   EMBL; CH940650; EDW66656.1; -; Genomic_DNA.
DR   RefSeq; XP_002053136.2; XM_002053100.2.
DR   AlphaFoldDB; B4LWT5; -.
DR   SMR; B4LWT5; -.
DR   STRING; 7244.FBpp0238136; -.
DR   PRIDE; B4LWT5; -.
DR   EnsemblMetazoa; FBtr0239644; FBpp0238136; FBgn0210816.
DR   GeneID; 6630890; -.
DR   KEGG; dvi:6630890; -.
DR   eggNOG; KOG3711; Eukaryota.
DR   HOGENOM; CLU_012654_1_0_1; -.
DR   InParanoid; B4LWT5; -.
DR   OMA; CMDEAPS; -.
DR   OrthoDB; 676663at2759; -.
DR   PhylomeDB; B4LWT5; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR   GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 2.
DR   Pfam; PF10221; DUF2151; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW   Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..681
FT                   /note="Protein asunder"
FT                   /id="PRO_0000385348"
FT   REGION          574..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           606..612
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT   COMPBIAS        581..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   681 AA;  75867 MW;  ADF361F7F929A1E8 CRC64;
     MFERNQKTIF VLDHTRYFSI SSEQYISMDY LKGKPVQETP ASGSSSMVVG TQLSKSLWTC
     AVESSIEYCR IVWDLFPGKK HVRFIVSDTA AHIVNTWSPS TQNMSHVSNA MMMVSVPSRS
     IPQSSDYSVI HGLRAAIEAL AEPTDEQLLA TQVGCKQIPN KGRVICITSA RDNTSMKSLE
     DIFNTVLLQQ NALVAPPSKK GLQIDHCHLV ILNIVPLGVE SLVTNRNLLE ISPLLDVEIH
     TVNAPDISDK LLHLIMGHYD LASTTVTNIP MKEEQNANSS ANYDVEILHE RAAHTRVCGP
     DFTLTTSIKP GTTYETVTLK WCTPRGCGSS DLQPCVGQYN VTPVDVTSRP SSCLINFLLN
     GRSVLLEVPR KTGTKTTSHM LSARGGEIFV HSLSIARSAM DEAPSISDGP GGRVSDYRIP
     ELGQLFKMSR MVPLKTKPKG KCSQGEHLWR RLPRYFPRTT NVTILFNLQR QLNWLPHFLH
     LIVKEDMDKQ DEVRCQQQIH ELYKSASRGD MLPFNTTNNA RPKVGKTKDQ YRLFYRELEQ
     LIQLNAQTPH HKNLLESLQS LRAAYGDVSS KLDPGASHLR SYTESPLSPE RLEPTSSASN
     SSSSILKASK RRMSSSGQRS LLDMISIAER SQSNKRLDFS GRLCTPLGQT AKLYPDFGNK
     EKDILTPGVV TSNLKDESIR S