ID   APOC4_RABIT             Reviewed;         124 AA.
AC   P55057;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Apolipoprotein C-IV;
DE            Short=Apo-CIV;
DE            Short=ApoC-IV;
DE   AltName: Full=Apolipoprotein C4;
DE   AltName: Full=PARP;
DE   Flags: Precursor;
GN   Name=APOC4;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   STRAIN=New Zealand; TISSUE=Liver;
RX   PubMed=8576182; DOI=10.1074/jbc.271.3.1776;
RA   Zhang L., Kotite L., Havel R.J.;
RT   "Identification, characterization, cloning, and expression of
RT   apolipoprotein C-IV, a novel sialoglycoprotein of rabbit plasma
RT   lipoproteins.";
RL   J. Biol. Chem. 271:1776-1783(1996).
CC   -!- FUNCTION: May participate in lipoprotein metabolism.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Blood plasma, associated primarily with VLDL and
CC       HDL. Expressed mainly in the liver.
CC   -!- PTM: Glycosylated; contains sialic acid. Present in up to five
CC       sialylated isoforms.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C4 family. {ECO:0000305}.
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DR   EMBL; U39356; AAC48513.1; -; mRNA.
DR   RefSeq; NP_001075834.1; NM_001082365.2.
DR   AlphaFoldDB; P55057; -.
DR   PRIDE; P55057; -.
DR   GeneID; 100009218; -.
DR   KEGG; ocu:100009218; -.
DR   CTD; 346; -.
DR   InParanoid; P55057; -.
DR   OrthoDB; 1563324at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028120; APOC4.
DR   PANTHER; PTHR32288; PTHR32288; 1.
DR   Pfam; PF15119; APOC4; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; HDL; Lipid transport;
KW   Reference proteome; Secreted; Signal; Transport; VLDL.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:8576182"
FT   CHAIN           28..124
FT                   /note="Apolipoprotein C-IV"
FT                   /id="PRO_0000002038"
SQ   SEQUENCE   124 AA;  14113 MW;  D4E42C51F078290C CRC64;
     MLLPRRGLRT LPSLCLYILV LVWVVACEPE GTPTPLPAPE ESRWSLVPSS VKELVGPLLT
     RTRERWQWFW GPGALQGFVQ TYYDDHLRDL GPRAQAWLTS SRDRLLNTAQ GLCPRLLCGD
     KDQD