ID   INT13_DROWI             Reviewed;         677 AA.
AC   B4NIM7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein asunder;
DE   AltName: Full=Cell cycle regulator Mat89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Maternal transcript 89Bb {ECO:0000250|UniProtKB:Q9VEX5};
DE   AltName: Full=Set apart in position or space protein;
GN   Name=asun; Synonyms=Mat89Bb; ORFNames=GK13769;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW83741.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000312|EMBL:EDW83741.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Plays a role as a regulator of spermatogenesis. Crucial
CC       regulator of the mitotic cell cycle and development. Required for the
CC       correct dynein-dynactin perinuclear localization important for nucleus-
CC       centrosome coupling that occur upon meiotic progression of primary
CC       spermatocytes. Crucial regulator of the mitotic cell cycle and
CC       development. Plays a role in sperm motility and fertility. May have a
CC       role in the PNG/PLU/GNU pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9VEX5}. Note=Colocalizes with dynein-dynactin
CC       on the nuclear surface at the meiotic G2/prophase transition in primary
CC       spermatocytes. Nuclear location is required for recruitment of dynein
CC       motors to nuclear envelope at G2/M. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9VEX5}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH964272; EDW83741.1; -; Genomic_DNA.
DR   RefSeq; XP_002072755.1; XM_002072719.2.
DR   AlphaFoldDB; B4NIM7; -.
DR   SMR; B4NIM7; -.
DR   STRING; 7260.FBpp0242912; -.
DR   EnsemblMetazoa; FBtr0244420; FBpp0242912; FBgn0215777.
DR   GeneID; 6650978; -.
DR   KEGG; dwi:6650978; -.
DR   eggNOG; KOG3711; Eukaryota.
DR   HOGENOM; CLU_012654_1_0_1; -.
DR   InParanoid; B4NIM7; -.
DR   OMA; CMDEAPS; -.
DR   OrthoDB; 676663at2759; -.
DR   PhylomeDB; B4NIM7; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032039; C:integrator complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR   GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051663; P:oocyte nucleus localization involved in oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0060814; P:posterior mRNA localization involved in anterior/posterior axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 2.
DR   Pfam; PF10221; DUF2151; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW   Differentiation; Meiosis; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..677
FT                   /note="Protein asunder"
FT                   /id="PRO_0000385349"
FT   REGION          578..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          515..540
FT                   /evidence="ECO:0000255"
FT   MOTIF           598..604
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VEX5"
FT   COMPBIAS        578..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   677 AA;  75198 MW;  868B1FA2DA80A427 CRC64;
     MFERNQKTIF VLDHTRYFSI ASEEYISMEY LKGKQTGLEA GANGGTQFSK SLWTCACESS
     IEYCRVVWDL FPGTKHVRFI VSDTAAHIVN TWSPSTQNMS HVMNAMVMVG VPSMPQSSDS
     SVIHGLRAAI EALAEPTDEQ MQAMGGKQTL HIPNEGRVIC ITSARDNTSM KSLEDIFHTV
     LVQQNSLMTS PPSKKGLPID HCHLVILNIV PLGVESLVTN RSLLEISPLL NVEIHTVPAP
     DISYKLTHLI LDHYELASTT VTNIPMKEEQ NANSSANYDV EILHSRQAHT IAGGPDFNLP
     TSIKTGSTYE TVTLKWCTPR GCSSADLQPC LGQFRVTPVD VTSRPSSCLI NFLLNGRSVL
     LEMPRKTGTK ATSHMLSARG GEIFVHALSI LRSCMDEAPA IQDGPGGRVT DYRFGELGQL
     IKLSRMIPLK AKDPSHPTHS TLRRRLPRYF PWTTSSSILF NLQRQINWLP HFLHLLVKED
     MDKQDEVRCQ QHIHELYKSA SRGDMLPFTN SNGGRLKLSK AKDQYRLLYR ELEQLIQLNS
     FTPHHKNLLE SLQSLRSAYG DAPTKSESAN ALLRSYTESP LSPERLEPTS SSSSNSLLKA
     RKRRMSTCGQ RSLFDIISSA ERSQSNKRLD FSGRLCTLPG QVAKLYPDFG NKDKDSLVIA
     GGVASTTASA KEESIRG