ID   INT13_XENLA             Reviewed;         715 AA.
AC   Q6GLY5;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Integrator complex subunit 13 {ECO:0000250|UniProtKB:Q9NVM9};
DE   AltName: Full=Cell cycle regulator Mat89Bb homolog {ECO:0000250|UniProtKB:Q9NVM9};
DE   AltName: Full=Germ cell tumor 1;
DE   AltName: Full=Protein asunder homolog {ECO:0000305};
DE   AltName: Full=Sarcoma antigen NY-SAR-95;
GN   Name=ints13 {ECO:0000250|UniProtKB:Q9NVM9};
GN   Synonyms=asun {ECO:0000250|UniProtKB:Q9NVM9}, mat89bb, net48;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH74308.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH74308.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=15737938; DOI=10.1016/j.devcel.2004.12.008;
RA   Lee L.A., Lee E., Anderson M.A., Vardy L., Tahinci E., Ali S.M.,
RA   Kashevsky H., Benasutti M., Kirschner M.W., Orr-Weaver T.L.;
RT   "Drosophila genome-scale screen for PAN GU kinase substrates identifies
RT   Mat89Bb as a cell cycle regulator.";
RL   Dev. Cell 8:435-442(2005).
CC   -!- FUNCTION: Crucial regulator of the mitotic cell cycle and development.
CC       At prophase, required for dynein anchoring to the nuclear envelope
CC       important for proper centrosome-nucleus coupling (By similarity). At
CC       G2/M phase, may be required for proper spindle formation and execution
CC       of cytokinesis (By similarity). Probable component of the Integrator
CC       (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1
CC       and U2 transcription and in their 3'-box-dependent processing (By
CC       similarity). Plays a role in gastrulation and early embryogenesis
CC       (PubMed:15737938). {ECO:0000250|UniProtKB:Q9NVM9,
CC       ECO:0000269|PubMed:15737938}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVM9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9NVM9}. Note=Nuclear location is required for
CC       recruitment of dynein motors to nuclear envelope at G2/M.
CC       {ECO:0000250|UniProtKB:Q9NVM9}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR   EMBL; BC074308; AAH74308.1; -; mRNA.
DR   RefSeq; NP_001086192.1; NM_001092723.1.
DR   AlphaFoldDB; Q6GLY5; -.
DR   SMR; Q6GLY5; -.
DR   MaxQB; Q6GLY5; -.
DR   DNASU; 444621; -.
DR   GeneID; 444621; -.
DR   KEGG; xla:444621; -.
DR   CTD; 444621; -.
DR   Xenbase; XB-GENE-997282; ints13.S.
DR   OrthoDB; 676663at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 444621; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 1.
DR   Pfam; PF10221; DUF2151; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Developmental protein; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Integrator complex subunit 13"
FT                   /id="PRO_0000389514"
FT   REGION          572..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          626..659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           581..591
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVM9"
FT   COMPBIAS        626..651
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  80967 MW;  C2EC17087CAB132A CRC64;
     MKTFSESHKT VFVVDHCPYM SESCRQHVEF DMLTKNRTQG IIPLAPISKS LWTCAVEASM
     EYCRIMYDIF PFRKLVNFIV SDSRSRTLNS WNREDQNLQE LMAALAVIGP PNPRADPECC
     SILHGLVEAV ESLCKITDFQ HESRTALMGN ADWVANRGRI ICITNAKSDS HVQMLEDCVN
     ETIHEHNKMA AGSDHLMQIQ KCHLVLLHTY PVGEDSLVSD RPKKELSNVL VSEVHSVKAG
     RHLSTKLNQL VQLHFDLAST TITNIPMKPT LSVCDQEEQH ANTSANYDVE LLHHKEAHVD
     FIKSGEGYTG SSSIRENSLK ETVTLKWCTP RTNSVELHYC TGAFRISPVD VNSRPSSCLT
     NFLLNGRSVL LEQPRKSGSK VISHMLSSHG GEIFLHVLSS SRSILEDPPS ISEGCGGRVT
     DYRITDFGEF MRENRLMPFP EQSYQMDGGP EVPLERAKEQ LERHTRYWPM IISQTTIFNM
     QAVVPLASVI VKESLSEEDL LNCQKTIYNL VDMERKNDPL PISTAGTRGK GPKRDEQYRI
     MWNELETLVR AHVSGSERHQ RVMECLMACR SKPPEEEERK KRGRKREDKE EKGEKLNKDH
     EHDKKGQESE RIKSVLDQEK EDLAEAEVIK DSPDSPEPPN KKPHIVIEDT GPAEKSKGPM
     SLLSLWSSRI NTANSRKHQE FVGRLNSVNN KAELYQHLKE ENGGEGVENG KASRQ