ID   INT13_XENTR             Reviewed;         707 AA.
AC   Q6DIK0;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Integrator complex subunit 13 {ECO:0000250|UniProtKB:Q9NVM9};
DE   AltName: Full=Cell cycle regulator Mat89Bb homolog {ECO:0000250|UniProtKB:Q6GLY5, ECO:0000250|UniProtKB:Q9NVM9};
DE   AltName: Full=Germ cell tumor 1;
DE   AltName: Full=Protein asunder homolog {ECO:0000305};
DE   AltName: Full=Sarcoma antigen NY-SAR-95;
GN   Name=ints13 {ECO:0000250|UniProtKB:Q9NVM9};
GN   Synonyms=asun {ECO:0000250|UniProtKB:Q9NVM9}, mat89bb;
GN   ORFNames=TGas007o21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83879.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83879.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ83879.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAH75538.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Crucial regulator of the mitotic cell cycle and development.
CC       At prophase, required for dynein anchoring to the nuclear envelope
CC       important for proper centrosome-nucleus coupling. At G2/M phase, may be
CC       required for proper spindle formation and execution of cytokinesis.
CC       Probable component of the Integrator (INT) complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC       3'-box-dependent processing (By similarity). Plays a role in
CC       gastrulation and early embryogenesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q6GLY5, ECO:0000250|UniProtKB:Q9NVM9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVM9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9NVM9}. Note=Nuclear location is required for
CC       recruitment of dynein motors to nuclear envelope at G2/M.
CC       {ECO:0000250|UniProtKB:Q9NVM9}.
CC   -!- SIMILARITY: Belongs to the asunder family. {ECO:0000305}.
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DR   EMBL; CR761707; CAJ83879.1; -; mRNA.
DR   EMBL; BC075538; AAH75538.1; -; mRNA.
DR   RefSeq; NP_001004984.1; NM_001004984.1.
DR   AlphaFoldDB; Q6DIK0; -.
DR   SMR; Q6DIK0; -.
DR   STRING; 8364.ENSXETP00000035984; -.
DR   PaxDb; Q6DIK0; -.
DR   DNASU; 448436; -.
DR   GeneID; 448436; -.
DR   KEGG; xtr:448436; -.
DR   CTD; 55726; -.
DR   Xenbase; XB-GENE-997276; ints13.
DR   eggNOG; KOG3711; Eukaryota.
DR   InParanoid; Q6DIK0; -.
DR   OrthoDB; 676663at2759; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.
DR   InterPro; IPR019355; Cell_cycle_regulator_Mat89Bb.
DR   PANTHER; PTHR12955; PTHR12955; 1.
DR   Pfam; PF10221; DUF2151; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Developmental protein;
KW   Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..707
FT                   /note="Integrator complex subunit 13"
FT                   /id="PRO_0000389515"
FT   REGION          565..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          567..622
FT                   /evidence="ECO:0000255"
FT   MOTIF           573..583
FT                   /note="Nuclear localization signal (NLS)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVM9"
FT   COMPBIAS        565..643
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  80285 MW;  46CE5073AA87B0B0 CRC64;
     MKTFSESHKT VFVVDHCPYM SESCRQHVEF DMLTKNRTQG IIPLAPISKS LWTCAIEASM
     EYCRIMYDIF PFRKLVNFIV SDSGSRTLNS WNQEDQNLQE LMAALAVIGP PNPRADPECC
     SILHGLVEAV ESLCKITDYQ HESRTELMEN ADRVANRGRI ICITNAKSDS HVQMLEDCVN
     ETIHEHNKLA AGSDHLMQIQ KCHLVLIHTY PVGEDSLVSD RPKKELSNVL ISEVHSVKAG
     RHLSTKLNQL VQLHFDLAST TITNIPMKEE QHANTSANYD VELLHHKEAH VEFNKSAGEG
     YNGSSSRENC LKETVTLKWC TPRTNSVELH YCTGAFRISP VDVNSRPSSC LTNFLLNGRS
     VLLEQPRKSG SKVISHMLSS HGGEIFLHVL SSSRSILEDP PSISEGCGGR VTDYRITDFG
     EFMRENRLMP FAEPRYCMDG GPEVPLERAK EQLERHTRYW PMIISQTTIF NMQAVVPLAS
     VIVKESLSEE DVLNCQKTIY NLVDMERKND PLPISTAGTR GKGPKRDEQY RIMWNELETL
     VRAHVRGSDR HQRVMDCLMA CRSKPPEEEE RKKRGRKRED KEEKAEKPPK ENEHEKKWQE
     SERVKSVLDR EKEDLAEAEV IKDSPDSPEP PNKKPHIMVE DTGPAEKSKG PMSLLSLWSS
     RINTANSRKH QEFVGRLNSV NNKAELYQHL KEENGAEGVE NGKGSRQ