INT14_BOVIN
ID INT14_BOVIN Reviewed; 518 AA.
AC Q5EA76;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000250|UniProtKB:Q96SY0};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000250|UniProtKB:Q96SY0};
GN Name=INTS14 {ECO:0000250|UniProtKB:Q96SY0};
GN Synonyms=VWA9 {ECO:0000250|UniProtKB:Q96SY0};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
CC -!- SIMILARITY: Belongs to the INTS14 family. {ECO:0000305}.
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DR EMBL; BT020693; AAX08710.1; -; mRNA.
DR EMBL; BC112684; AAI12685.1; -; mRNA.
DR RefSeq; NP_001015652.1; NM_001015652.3.
DR RefSeq; XP_005211402.1; XM_005211345.3.
DR AlphaFoldDB; Q5EA76; -.
DR SMR; Q5EA76; -.
DR STRING; 9913.ENSBTAP00000020164; -.
DR PaxDb; Q5EA76; -.
DR PRIDE; Q5EA76; -.
DR Ensembl; ENSBTAT00000020164; ENSBTAP00000020164; ENSBTAG00000015158.
DR GeneID; 534159; -.
DR KEGG; bta:534159; -.
DR CTD; 81556; -.
DR VEuPathDB; HostDB:ENSBTAG00000015158; -.
DR VGNC; VGNC:30227; INTS14.
DR eggNOG; ENOG502QQ37; Eukaryota.
DR GeneTree; ENSGT00390000009486; -.
DR HOGENOM; CLU_041485_0_0_1; -.
DR InParanoid; Q5EA76; -.
DR OMA; WIRQASL; -.
DR OrthoDB; 1453503at2759; -.
DR TreeFam; TF323245; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000015158; Expressed in semen and 108 other tissues.
DR ExpressionAtlas; Q5EA76; baseline and differential.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532; PTHR13532; 1.
DR Pfam; PF19435; IntS14; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Nucleus; Reference proteome.
FT CHAIN 1..518
FT /note="Integrator complex subunit 14"
FT /id="PRO_0000296267"
FT DOMAIN 2..204
FT /note="VWFA"
FT MOD_RES 418
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q96SY0"
SQ SEQUENCE 518 AA; 57406 MW; 10D07315BDC8FC51 CRC64;
MPTVVVMDVS LSMTRPVSVE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW
ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG
IGRGSLRHSL ATHNQRGESN RFPLPFPFPS KLYIMCMANL EELQSTDSLD CLERLIDLNN
GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVIDEEI
DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN
QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWHGMLYSQA DSKKKSNLMM SLFEPGPEPL
PWLGKMVQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
HAAQQLKLAS TGTSEYAGYD HNITPLQTDF SGSSAERI
