APOC4_RAT
ID APOC4_RAT Reviewed; 124 AA.
AC P55797;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Apolipoprotein C-IV;
DE Short=Apo-CIV;
DE Short=ApoC-IV;
DE AltName: Full=Apolipoprotein C4;
DE AltName: Full=Apolipoprotein E-linked;
DE AltName: Full=ECL;
DE Flags: Precursor;
GN Name=Apoc4; Synonyms=Ecl;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=1379790; DOI=10.1016/0003-9861(92)90683-n;
RA Shen P., Howlett G.J.;
RT "Two coding regions closely linked to the rat apolipoprotein E gene:
RT nucleotide sequences of rat apolipoprotein C-I and ECL cDNA.";
RL Arch. Biochem. Biophys. 297:345-353(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Lee N.H., Glodek A., Chandra I., Mason T.M., Quackenbush J.,
RA Kerlavage A.R., Adams M.D.;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May participate in lipoprotein metabolism.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P55797-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P55797-2; Sequence=VSP_022002;
CC -!- SIMILARITY: Belongs to the apolipoprotein C4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA39653.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; X56190; CAA39653.1; ALT_SEQ; mRNA.
DR EMBL; AA945171; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; S25719; S25719.
DR RefSeq; NP_001102889.1; NM_001109419.1. [P55797-1]
DR AlphaFoldDB; P55797; -.
DR IntAct; P55797; 1.
DR STRING; 10116.ENSRNOP00000024832; -.
DR iPTMnet; P55797; -.
DR PhosphoSitePlus; P55797; -.
DR PaxDb; P55797; -.
DR Ensembl; ENSRNOT00000024832; ENSRNOP00000024832; ENSRNOG00000018405. [P55797-1]
DR GeneID; 680551; -.
DR KEGG; rno:680551; -.
DR UCSC; RGD:70959; rat. [P55797-1]
DR CTD; 346; -.
DR RGD; 70959; Apoc4.
DR eggNOG; ENOG502TE52; Eukaryota.
DR GeneTree; ENSGT00390000015914; -.
DR HOGENOM; CLU_161459_0_0_1; -.
DR InParanoid; P55797; -.
DR OMA; KWQWFWG; -.
DR OrthoDB; 1563324at2759; -.
DR PhylomeDB; P55797; -.
DR TreeFam; TF336879; -.
DR Reactome; R-RNO-8866423; VLDL assembly.
DR Reactome; R-RNO-8964046; VLDL clearance.
DR PRO; PR:P55797; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000018405; Expressed in liver and 15 other tissues.
DR Genevisible; P55797; RN.
DR GO; GO:0034364; C:high-density lipoprotein particle; ISO:RGD.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; ISO:RGD.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0010890; P:positive regulation of sequestering of triglyceride; ISO:RGD.
DR GO; GO:0070328; P:triglyceride homeostasis; ISO:RGD.
DR InterPro; IPR028120; APOC4.
DR PANTHER; PTHR32288; PTHR32288; 1.
DR Pfam; PF15119; APOC4; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Lipid transport; Reference proteome; Secreted;
KW Signal; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000250|UniProtKB:P55057"
FT CHAIN 28..124
FT /note="Apolipoprotein C-IV"
FT /id="PRO_0000002039"
FT VAR_SEQ 70..124
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:1379790"
FT /id="VSP_022002"
SQ SEQUENCE 124 AA; 14532 MW; 8C7CB8975D95D81F CRC64;
MSLLRCRQQT LPSLCLSVLF LACFVASMPT ESLTPTPGPE NSRWSLVRAR VMEMVEPLVT
RTRDRWRWFW GPRAIQGFVQ TYYEDHLKDL GPRTQAWLQS SRDHLLNKTH SLCPRLLCRD
WTQG
