ID   INT14_RAT               Reviewed;         515 AA.
AC   Q66H58;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000312|RGD:1359616};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000305};
GN   Name=Ints14 {ECO:0000312|RGD:1359616};
GN   Synonyms=Vwa9 {ECO:0000312|RGD:1359616};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SIMILARITY: Belongs to the INTS14 family. {ECO:0000305}.
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DR   EMBL; BC082006; AAH82006.1; -; mRNA.
DR   RefSeq; NP_001007664.1; NM_001007663.1.
DR   RefSeq; XP_008764460.1; XM_008766238.1.
DR   RefSeq; XP_008764461.1; XM_008766239.2.
DR   AlphaFoldDB; Q66H58; -.
DR   SMR; Q66H58; -.
DR   STRING; 10116.ENSRNOP00000016798; -.
DR   PaxDb; Q66H58; -.
DR   Ensembl; ENSRNOT00000016798; ENSRNOP00000016798; ENSRNOG00000012469.
DR   GeneID; 300782; -.
DR   KEGG; rno:300782; -.
DR   UCSC; RGD:1359616; rat.
DR   CTD; 81556; -.
DR   RGD; 1359616; Ints14.
DR   eggNOG; ENOG502QQ37; Eukaryota.
DR   GeneTree; ENSGT00390000009486; -.
DR   HOGENOM; CLU_041485_0_0_1; -.
DR   InParanoid; Q66H58; -.
DR   OMA; WIRQASL; -.
DR   OrthoDB; 1453503at2759; -.
DR   PhylomeDB; Q66H58; -.
DR   TreeFam; TF323245; -.
DR   Reactome; R-RNO-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q66H58; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000012469; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q66H58; RN.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532; PTHR13532; 1.
DR   Pfam; PF19435; IntS14; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome.
FT   CHAIN           1..515
FT                   /note="Integrator complex subunit 14"
FT                   /id="PRO_0000296269"
FT   DOMAIN          2..204
FT                   /note="VWFA"
FT   MOD_RES         418
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96SY0"
SQ   SEQUENCE   515 AA;  57144 MW;  D54837B3116C3AE9 CRC64;
     MPTVVVMDVS LSMTRPVSVE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW
     ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG
     IGRGSLRHSL ATQNQRSESS RFPLPFPFPS KLYVMCMANL EELQSTDSLE CLERLIDLNN
     GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAALKCGH LTADVQVFPR PEPFVIDEEI
     DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGAGIT DDNEDENSAN
     QIAGKIPNFC VLLHGSLKVE GMVALVQLGP EWHGMLYSQA DSKKKSNLMM SLFEPGPEPL
     PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
     RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
     HAAQQLKLAS TEYAVYDLNI TPLHTDFSGS STERM