ID   INT14_XENTR             Reviewed;         518 AA.
AC   Q66KD9;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000250|UniProtKB:Q96SY0};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000305};
GN   Name=ints14 {ECO:0000250|UniProtKB:Q96SY0}; Synonyms=vwa9 {ECO:0000305};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9VPY0}.
CC   -!- SIMILARITY: Belongs to the INTS14 family. {ECO:0000305}.
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DR   EMBL; BC080444; AAH80444.1; -; mRNA.
DR   RefSeq; NP_001007939.1; NM_001007938.1.
DR   RefSeq; XP_012814335.1; XM_012958881.2.
DR   AlphaFoldDB; Q66KD9; -.
DR   SMR; Q66KD9; -.
DR   STRING; 8364.ENSXETP00000063118; -.
DR   DNASU; 493315; -.
DR   GeneID; 493315; -.
DR   KEGG; xtr:493315; -.
DR   CTD; 81556; -.
DR   Xenbase; XB-GENE-978854; ints14.
DR   eggNOG; ENOG502QQ37; Eukaryota.
DR   InParanoid; Q66KD9; -.
DR   OrthoDB; 1453503at2759; -.
DR   Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532; PTHR13532; 1.
DR   Pfam; PF19435; IntS14; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..518
FT                   /note="Integrator complex subunit 14"
FT                   /id="PRO_0000296271"
FT   DOMAIN          2..204
FT                   /note="VWFA"
SQ   SEQUENCE   518 AA;  57322 MW;  BE3831E70DD9D303 CRC64;
     MPTVVVMDVS LSMTRPVPVE GTEEFQRKHL AVHGLTMLFE HMATNYKLEF TAMVVFSSLW
     ELMVPFTRDY NTLQEALSNI DDYDKTCLES ALQGVSSVVQ QEWGASIPSQ IVLVTDGCLG
     IGKGSLQHSL ATLNQRNDSN RFPLPFSFPS KLYIMCMANL EELQGSDSLE YLERLIDLNN
     GEGQIFTIDG PLCLKNVQSM FGKLIDVAYT PFHAVLKCGN LSSDVQVFPR PEPVITDEEI
     DPLPKTINTD LEVVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGLA DDMEDENSAN
     QIAGKIPNFC VLLHGSLKVE GMVALVQLGP DWHGMLYSQA DSKKKSNLMM SLFEPGLEPL
     PWLGKTMQLG PITDAKENPY GEEDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
     RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVSDML ERECTLLPDT AHPDAAFQLS
     HAAAQLKLAS TGGSEHGAYD HNIVPLQTDF SGRNSDRI