INT15_DANRE
ID INT15_DANRE Reviewed; 475 AA.
AC Q7ZTY6; Q6NYU1;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Integrator complex subunit 15;
GN Name=ints15; ORFNames=zgc:56409;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q96N11}.
CC -!- SUBUNIT: Probable component of the multiprotein Integrator (INT)
CC complex. {ECO:0000250|UniProtKB:Q96N11}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96N11}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7ZTY6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7ZTY6-2; Sequence=VSP_036204;
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DR EMBL; BC052107; AAH52107.1; -; mRNA.
DR EMBL; BC066462; AAH66462.1; -; mRNA.
DR RefSeq; NP_956619.1; NM_200325.1.
DR RefSeq; XP_005170908.1; XM_005170851.3. [Q7ZTY6-1]
DR AlphaFoldDB; Q7ZTY6; -.
DR STRING; 7955.ENSDARP00000054842; -.
DR PaxDb; Q7ZTY6; -.
DR Ensembl; ENSDART00000054843; ENSDARP00000054842; ENSDARG00000037652. [Q7ZTY6-1]
DR Ensembl; ENSDART00000138630; ENSDARP00000119765; ENSDARG00000037652. [Q7ZTY6-2]
DR GeneID; 393295; -.
DR KEGG; dre:393295; -.
DR CTD; 79034; -.
DR ZFIN; ZDB-GENE-040426-1019; zgc:56409.
DR eggNOG; ENOG502QW9D; Eukaryota.
DR GeneTree; ENSGT00390000011370; -.
DR HOGENOM; CLU_045490_1_0_1; -.
DR InParanoid; Q7ZTY6; -.
DR OMA; YPAHAAH; -.
DR OrthoDB; 1387798at2759; -.
DR PhylomeDB; Q7ZTY6; -.
DR TreeFam; TF324587; -.
DR PRO; PR:Q7ZTY6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000037652; Expressed in early embryo and 20 other tissues.
DR GO; GO:0032039; C:integrator complex; ISS:UniProtKB.
DR InterPro; IPR027844; DUF4507.
DR PANTHER; PTHR14540; PTHR14540; 1.
DR Pfam; PF14964; DUF4507; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..475
FT /note="Integrator complex subunit 15"
FT /id="PRO_0000360411"
FT REGION 402..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 403..425
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036204"
FT CONFLICT 5
FT /note="R -> Q (in Ref. 1; AAH52107)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="S -> P (in Ref. 1; AAH52107)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="A -> T (in Ref. 1; AAH52107)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="D -> E (in Ref. 1; AAH52107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 52353 MW; F145D0C4DC7BD3AD CRC64;
MSDIRHALLR RDPLSAAKEV LYHLDISLGS ALQSSAGPPA GLEKSTVELV EEFIFHVSKD
RNIQSKRMSC VQELQLLEII CSYFQEQSKD AIRQVIFSAL FSLQGNKADE SRMAMLGKLV
SMSIAVCRVP ILECAAIWLQ RTHSAWCVRL AQVLMEDYCT LVPCAISTLQ NICSASPRFC
CQLITAVTAL YDFSTDELTP PPALLEMLVG WITEDPRLLL LTFINSPLNS SLPLGCLEIT
PLLGLLRWCV KAPLAYHRGR KSAMTNGHGD GEKGTAYEEL YSKLHLSVLQ VFLMLQVHLT
EKNMFCRLTV LPVESVAALI EEVGRLCEKL APLLDASHIQ LALDRLAQAL QVAMATGALL
CAREDLRALC SRLPHNNLLQ LVMSGPVVQP PPHSSPFQPN MYPHIHPGRP SPLSPHSPHQ
STLSSPHSPH TVLTAHPTHP ALAPHRPLTA HATHPALSPH AFHPASIAFP YRPIR
