ID   INT15_MOUSE             Reviewed;         448 AA.
AC   Q8BGA7; Q3T9D0; Q8BN55;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Integrator complex subunit 15;
GN   Name=Ints15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Eye, Spleen, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q96N11}.
CC   -!- SUBUNIT: Probable component of the multiprotein Integrator (INT)
CC       complex. {ECO:0000250|UniProtKB:Q96N11}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96N11}.
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DR   EMBL; AK041667; BAC31026.1; -; mRNA.
DR   EMBL; AK050733; BAC34397.1; -; mRNA.
DR   EMBL; AK053801; BAC35532.1; -; mRNA.
DR   EMBL; AK087531; BAC39915.1; -; mRNA.
DR   EMBL; AK172614; BAE43094.1; -; mRNA.
DR   EMBL; BC079853; AAH79853.1; -; mRNA.
DR   EMBL; BC082321; AAH82321.1; -; mRNA.
DR   CCDS; CCDS19839.1; -.
DR   RefSeq; NP_766314.3; NM_172726.4.
DR   AlphaFoldDB; Q8BGA7; -.
DR   STRING; 10090.ENSMUSP00000041800; -.
DR   iPTMnet; Q8BGA7; -.
DR   PhosphoSitePlus; Q8BGA7; -.
DR   EPD; Q8BGA7; -.
DR   MaxQB; Q8BGA7; -.
DR   PaxDb; Q8BGA7; -.
DR   PeptideAtlas; Q8BGA7; -.
DR   PRIDE; Q8BGA7; -.
DR   Antibodypedia; 64371; 39 antibodies from 12 providers.
DR   DNASU; 231868; -.
DR   Ensembl; ENSMUST00000046418; ENSMUSP00000041800; ENSMUSG00000039244.
DR   GeneID; 231868; -.
DR   KEGG; mmu:231868; -.
DR   UCSC; uc009ajy.2; mouse.
DR   CTD; 231868; -.
DR   MGI; MGI:2442621; E130309D02Rik.
DR   VEuPathDB; HostDB:ENSMUSG00000039244; -.
DR   eggNOG; ENOG502QW9D; Eukaryota.
DR   GeneTree; ENSGT00390000011370; -.
DR   HOGENOM; CLU_045490_1_0_1; -.
DR   InParanoid; Q8BGA7; -.
DR   OMA; YPAHAAH; -.
DR   OrthoDB; 1387798at2759; -.
DR   PhylomeDB; Q8BGA7; -.
DR   TreeFam; TF324587; -.
DR   BioGRID-ORCS; 231868; 14 hits in 73 CRISPR screens.
DR   PRO; PR:Q8BGA7; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q8BGA7; protein.
DR   Bgee; ENSMUSG00000039244; Expressed in rostral migratory stream and 263 other tissues.
DR   Genevisible; Q8BGA7; MM.
DR   GO; GO:0032039; C:integrator complex; ISS:UniProtKB.
DR   InterPro; IPR027844; DUF4507.
DR   PANTHER; PTHR14540; PTHR14540; 1.
DR   Pfam; PF14964; DUF4507; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..448
FT                   /note="Integrator complex subunit 15"
FT                   /id="PRO_0000089583"
FT   CONFLICT        3
FT                   /note="D -> E (in Ref. 1; BAC39915)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="D -> N (in Ref. 1; BAC39915)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   448 AA;  49908 MW;  AFC265028B5EA33D CRC64;
     MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGSVELLEE FVFQVPKERG
     AQPKRLNSLQ ELQLLEIMCS YFQEQSKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM
     AVAVCRIPVL ECAASWLQRT PVVYCVRLAR VLVEDYCCLV PGSVQTLKQI FSASPRFCCQ
     FITSVTALYD LSSDDLIPPL DLLEMIVSWI FEDPRLILIT FLNTPIAANL PIGFLELTPL
     IGLIRWCVKA PLAYKRKKPC LSNGHISHKV AKDSGASTDR DSHLLYSKLH LSVLQVLMTL
     QLHLTEKNLY GRLGLILFDH MVPLVEEINR LADELNPLNA SQEIELALDR LAQALQVAMT
     SGALLCTRDD LRTLCSRLPH NNLLQLVISG PVQQSPHTAL PPGFYPHIHT PPLAYGAVPA
     HPAAHPALPT HPGHTFISGV TFPFRPIR