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INT1_DICDI
ID   INT1_DICDI              Reviewed;        2497 AA.
AC   Q54NC8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Integrator complex subunit 1 homolog;
GN   Name=ints1; ORFNames=DDB_G0285393;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64771.1; -; Genomic_DNA.
DR   RefSeq; XP_638252.1; XM_633160.1.
DR   AlphaFoldDB; Q54NC8; -.
DR   STRING; 44689.DDB0234073; -.
DR   PaxDb; Q54NC8; -.
DR   PRIDE; Q54NC8; -.
DR   EnsemblProtists; EAL64771; EAL64771; DDB_G0285393.
DR   GeneID; 8625060; -.
DR   KEGG; ddi:DDB_G0285393; -.
DR   dictyBase; DDB_G0285393; ints1.
DR   eggNOG; KOG4596; Eukaryota.
DR   HOGENOM; CLU_228556_0_0_1; -.
DR   InParanoid; Q54NC8; -.
DR   OMA; FDICKEW; -.
DR   PRO; PR:Q54NC8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034474; P:U2 snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR038902; INTS1.
DR   PANTHER; PTHR21224; PTHR21224; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome.
FT   CHAIN           1..2497
FT                   /note="Integrator complex subunit 1 homolog"
FT                   /id="PRO_0000344373"
FT   REGION          1..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          946..965
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1028..1108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1234..1292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1572..1604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2084..2123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2329..2350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1645..1675
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        30..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2084..2116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2497 AA;  284509 MW;  E45325556B260531 CRC64;
     MMLNKIKRSK AGSIEDSKLQ ALPLGTRRKI GQTTGESDNN NNNSNDQSLK KFKNDNTEEN
     NSIGVNNNTS TNININTNTN INTNNSTNTN NINNTNNNNN NNNNNNNNNN NNNNNNNNNS
     NNNNNNNISN GGNNINNNNN NNNNGNNNNN INNSNGIRRV FDQNYYIDLV ESEEDIEIKI
     RIIKSMLMVL KSSVGNEPDK CAFISLLVIC KRSPTLFSHF DLLEPLLSLL KKDPTHVQKK
     NNLLSILACN LLMAGYDHIQ DWPVYLFCAY LDDAIGDRYW VEDQYCKTFV NNIITAFPQQ
     PQPPQQQQTK QPVNIKTQPQ QQQQQQQQPQ PQQIKKSDDD IVEEIDNLLS VSSSSQPQPQ
     QQKNRFSHCL NDIIKYIIHM IRQYIQSPNQ RVFIKLLSLT VGFKESRLEG SQIIEQLLGN
     TNVFRFAKEY LTQLLAATTE STVEDIKTVQ NLLKIQVSHH IDIISTLLVN NPIYPAIALH
     QAIEIELDTN QKVATKSKLS IIFKFLPNNR GEEELAMILK DFCSRDDSIR SPVKIIVKKI
     LKNLTFISLF YLCEQLSTIT QKDEQFYLLL QSSQQQQQQQ PPPSTITITR ERWALNIIHM
     LTQILFLIPS MNEHLKDQSN MRSMISTIQS SSVSWCFKLL NLGVLSYGDA LSLIGKVLIF
     EPLNSFFQAP NLAVDSDRNA YRMLTTEIPI QENILDILLT IGFEYPSEKK IVLELCEALL
     KRAISIVHKF NVLVPLTKVT FAESILSLSR IENTSEPQLA YTSLFWQSTI LACLLICLSP
     SIIGSYYWNN CPTIRILIEM IITRSWKFPP YLPKAVANNP SYFQLIEQNQ RIEEKKLLSR
     IPQLTSIDFM ILDSIKGTNG VIRQPPEEII EKLQKLDNDF HLGFILCNCR SPDFLLDIMS
     NQDSKQSMMW LNPIIHNDPK TLDILPPICL SEILLSTQFE QQQQQQQQQQ QLQTPQQQQQ
     QQQPTNPIAP RVLNRMSLFF NSPSPVPTLE ILNFFFTLLC SDNPIIRILS KKSLSLLVLP
     IKSTLSTTTT TTSSTTTTTT TTTSTTTSTS TSSSSSSLNP TQPSLRSSCD KIKTSGLSGS
     SNGINQSSDS ITAVAGSTSP TTTTTSSSST CQTYITEEFQ WLLKLNNLAW FEESQEIVIS
     ALKKAINVET DVSSIRSYIQ YLVVNQSTPF DASFQMDLSQ LILNRGIIAN YLLSSDISIL
     IFNAYLNILE PLNQKDLSKK LLLLSSSTNS INNINNNDNN NNNNNNNNNN NNNNNNNNND
     NNINKNNDDN NHSNSMANNN LPNNNNKNNQ KSKKWVKIIK NSNNKNNDDN SMEDDNNEDI
     IYLPRIVLDS IIYCISSSLN VNDIDQIQSI VAILFPTTTT TAIDQDKTFE IKNKFLDFDN
     QTDEEPILKS KQLVEVSLKS SIPQLISIAL QRNTSVGLFN GLNDYIEQLI LKGIEMSFLS
     RSMILEIIDK NIDKIKSSFE NNSSNNDNNE SKEIKEILNQ IIENNEKQTI LKLFIKESSK
     HGQLFLNFIE SLISAKSGDS KQITKKKQKS SFNLFNEFLE TDEINNQEIE EGSMELDINF
     ENSIKHQILN INNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNITQLLEGN GQIDSFVKAI
     NSFEVSKSIS SDININIPFS ISTIRILKNT TQQKQQKQQQ KESVQKSIQS LSKLILSSKN
     IKNYQKRFID HILKKKSNLE LIESAQNLTL ENGINKEFDI CKEWEIYSSG SGSSSNEIND
     QFKGTEIIRK LVNKQHFSII IVSDPLKLGE IFKSLVKQFI LNDQLRLEEF IGGFFTKVYS
     NSLSQSSTIT IVLFNSLVSL LTDFGSNIQM KQSLGILLDW TGLLVQQFLL KNNNNNNNNN
     NNGISLNIKQ FYFLLFGKGS FKFSTLLHSH FIHNSTWRNL KIMMQWLFKV NNNYNDDDDD
     NDDGDRPIID ATLVLNFINA YHQHPRSGAP YYSASNTATT ASSKSITNMS TIMDSMVMHY
     LNPSTIRTLS DYIIEEIDQV KGGPSNYPQS KLRNRMNLLI SSSMISKENL ISLVLHLSNQ
     YTKSTSSSIV IKQIYFAFPS TLKSILTNFS PCLIVSSPNN LLSQQQQQQQ QQQQQQQKQQ
     SNNSNNINNN NNNNNSEKKQ KSKEQNIILT TNDLIVNNQS IPSTQLDIIL HRVILKISDM
     STIENRNSGF IIVRKLAILH PELITLHLPS FYSLLSGRAD TPLTLFLSRN YHHLFYQILD
     LLDILRPIVF NSQSLLPILQ EYFTLFSNNC NQRINDFIPI VSKLCDFLLP FTGNYQNLDI
     LIQNKDTIKS LSIFYPNAEP LLLRIKPNQI SSLSSSYYLS SLLSINNNNN NNNNNNNNNN
     NNNNNNNNNN NNPLELIKFK LYDNGYNNNN NDKLVKQLED VIKITQNLPS YLHCIKDELL
     RLIQSDYQNI RAISYFLIQR YLQYCPQDAE SMMDKYLSCF QHWNPDVVKD AIQHSSDFYC
     LSNDRSEYLI EQILIYGGKD SINDIKKLIN PFSRIFY
 
 
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