INT1_DICDI
ID INT1_DICDI Reviewed; 2497 AA.
AC Q54NC8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Integrator complex subunit 1 homolog;
GN Name=ints1; ORFNames=DDB_G0285393;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC box-dependent processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 1 family. {ECO:0000305}.
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DR EMBL; AAFI02000079; EAL64771.1; -; Genomic_DNA.
DR RefSeq; XP_638252.1; XM_633160.1.
DR AlphaFoldDB; Q54NC8; -.
DR STRING; 44689.DDB0234073; -.
DR PaxDb; Q54NC8; -.
DR PRIDE; Q54NC8; -.
DR EnsemblProtists; EAL64771; EAL64771; DDB_G0285393.
DR GeneID; 8625060; -.
DR KEGG; ddi:DDB_G0285393; -.
DR dictyBase; DDB_G0285393; ints1.
DR eggNOG; KOG4596; Eukaryota.
DR HOGENOM; CLU_228556_0_0_1; -.
DR InParanoid; Q54NC8; -.
DR OMA; FDICKEW; -.
DR PRO; PR:Q54NC8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034474; P:U2 snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR038902; INTS1.
DR PANTHER; PTHR21224; PTHR21224; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..2497
FT /note="Integrator complex subunit 1 homolog"
FT /id="PRO_0000344373"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2084..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2329..2350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1645..1675
FT /evidence="ECO:0000255"
FT COMPBIAS 30..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2084..2116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2497 AA; 284509 MW; E45325556B260531 CRC64;
MMLNKIKRSK AGSIEDSKLQ ALPLGTRRKI GQTTGESDNN NNNSNDQSLK KFKNDNTEEN
NSIGVNNNTS TNININTNTN INTNNSTNTN NINNTNNNNN NNNNNNNNNN NNNNNNNNNS
NNNNNNNISN GGNNINNNNN NNNNGNNNNN INNSNGIRRV FDQNYYIDLV ESEEDIEIKI
RIIKSMLMVL KSSVGNEPDK CAFISLLVIC KRSPTLFSHF DLLEPLLSLL KKDPTHVQKK
NNLLSILACN LLMAGYDHIQ DWPVYLFCAY LDDAIGDRYW VEDQYCKTFV NNIITAFPQQ
PQPPQQQQTK QPVNIKTQPQ QQQQQQQQPQ PQQIKKSDDD IVEEIDNLLS VSSSSQPQPQ
QQKNRFSHCL NDIIKYIIHM IRQYIQSPNQ RVFIKLLSLT VGFKESRLEG SQIIEQLLGN
TNVFRFAKEY LTQLLAATTE STVEDIKTVQ NLLKIQVSHH IDIISTLLVN NPIYPAIALH
QAIEIELDTN QKVATKSKLS IIFKFLPNNR GEEELAMILK DFCSRDDSIR SPVKIIVKKI
LKNLTFISLF YLCEQLSTIT QKDEQFYLLL QSSQQQQQQQ PPPSTITITR ERWALNIIHM
LTQILFLIPS MNEHLKDQSN MRSMISTIQS SSVSWCFKLL NLGVLSYGDA LSLIGKVLIF
EPLNSFFQAP NLAVDSDRNA YRMLTTEIPI QENILDILLT IGFEYPSEKK IVLELCEALL
KRAISIVHKF NVLVPLTKVT FAESILSLSR IENTSEPQLA YTSLFWQSTI LACLLICLSP
SIIGSYYWNN CPTIRILIEM IITRSWKFPP YLPKAVANNP SYFQLIEQNQ RIEEKKLLSR
IPQLTSIDFM ILDSIKGTNG VIRQPPEEII EKLQKLDNDF HLGFILCNCR SPDFLLDIMS
NQDSKQSMMW LNPIIHNDPK TLDILPPICL SEILLSTQFE QQQQQQQQQQ QLQTPQQQQQ
QQQPTNPIAP RVLNRMSLFF NSPSPVPTLE ILNFFFTLLC SDNPIIRILS KKSLSLLVLP
IKSTLSTTTT TTSSTTTTTT TTTSTTTSTS TSSSSSSLNP TQPSLRSSCD KIKTSGLSGS
SNGINQSSDS ITAVAGSTSP TTTTTSSSST CQTYITEEFQ WLLKLNNLAW FEESQEIVIS
ALKKAINVET DVSSIRSYIQ YLVVNQSTPF DASFQMDLSQ LILNRGIIAN YLLSSDISIL
IFNAYLNILE PLNQKDLSKK LLLLSSSTNS INNINNNDNN NNNNNNNNNN NNNNNNNNND
NNINKNNDDN NHSNSMANNN LPNNNNKNNQ KSKKWVKIIK NSNNKNNDDN SMEDDNNEDI
IYLPRIVLDS IIYCISSSLN VNDIDQIQSI VAILFPTTTT TAIDQDKTFE IKNKFLDFDN
QTDEEPILKS KQLVEVSLKS SIPQLISIAL QRNTSVGLFN GLNDYIEQLI LKGIEMSFLS
RSMILEIIDK NIDKIKSSFE NNSSNNDNNE SKEIKEILNQ IIENNEKQTI LKLFIKESSK
HGQLFLNFIE SLISAKSGDS KQITKKKQKS SFNLFNEFLE TDEINNQEIE EGSMELDINF
ENSIKHQILN INNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNITQLLEGN GQIDSFVKAI
NSFEVSKSIS SDININIPFS ISTIRILKNT TQQKQQKQQQ KESVQKSIQS LSKLILSSKN
IKNYQKRFID HILKKKSNLE LIESAQNLTL ENGINKEFDI CKEWEIYSSG SGSSSNEIND
QFKGTEIIRK LVNKQHFSII IVSDPLKLGE IFKSLVKQFI LNDQLRLEEF IGGFFTKVYS
NSLSQSSTIT IVLFNSLVSL LTDFGSNIQM KQSLGILLDW TGLLVQQFLL KNNNNNNNNN
NNGISLNIKQ FYFLLFGKGS FKFSTLLHSH FIHNSTWRNL KIMMQWLFKV NNNYNDDDDD
NDDGDRPIID ATLVLNFINA YHQHPRSGAP YYSASNTATT ASSKSITNMS TIMDSMVMHY
LNPSTIRTLS DYIIEEIDQV KGGPSNYPQS KLRNRMNLLI SSSMISKENL ISLVLHLSNQ
YTKSTSSSIV IKQIYFAFPS TLKSILTNFS PCLIVSSPNN LLSQQQQQQQ QQQQQQQKQQ
SNNSNNINNN NNNNNSEKKQ KSKEQNIILT TNDLIVNNQS IPSTQLDIIL HRVILKISDM
STIENRNSGF IIVRKLAILH PELITLHLPS FYSLLSGRAD TPLTLFLSRN YHHLFYQILD
LLDILRPIVF NSQSLLPILQ EYFTLFSNNC NQRINDFIPI VSKLCDFLLP FTGNYQNLDI
LIQNKDTIKS LSIFYPNAEP LLLRIKPNQI SSLSSSYYLS SLLSINNNNN NNNNNNNNNN
NNNNNNNNNN NNPLELIKFK LYDNGYNNNN NDKLVKQLED VIKITQNLPS YLHCIKDELL
RLIQSDYQNI RAISYFLIQR YLQYCPQDAE SMMDKYLSCF QHWNPDVVKD AIQHSSDFYC
LSNDRSEYLI EQILIYGGKD SINDIKKLIN PFSRIFY