ID   INT2_CHICK              Reviewed;        1192 AA.
AC   Q5ZKU4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Integrator complex subunit 2;
DE            Short=Int2;
GN   Name=INTS2; ORFNames=RCJMB04_9c3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9H0H0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q9H0H0};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H0H0}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 2 family. {ECO:0000305}.
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DR   EMBL; AJ719990; CAG31649.1; -; mRNA.
DR   RefSeq; NP_001025893.1; NM_001030722.1.
DR   AlphaFoldDB; Q5ZKU4; -.
DR   SMR; Q5ZKU4; -.
DR   STRING; 9031.ENSGALP00000008442; -.
DR   PaxDb; Q5ZKU4; -.
DR   GeneID; 417640; -.
DR   KEGG; gga:417640; -.
DR   CTD; 57508; -.
DR   VEuPathDB; HostDB:geneid_417640; -.
DR   eggNOG; ENOG502QSP2; Eukaryota.
DR   InParanoid; Q5ZKU4; -.
DR   OrthoDB; 173270at2759; -.
DR   PhylomeDB; Q5ZKU4; -.
DR   PRO; PR:Q5ZKU4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR026236; Int2_metazoa.
DR   InterPro; IPR029321; INTS2.
DR   PANTHER; PTHR28608; PTHR28608; 1.
DR   Pfam; PF14750; INTS2; 1.
DR   PRINTS; PR02105; INTSUBUNIT2.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1192
FT                   /note="Integrator complex subunit 2"
FT                   /id="PRO_0000236101"
FT   TRANSMEM        420..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1192 AA;  132884 MW;  D6C6EB45D013D5DB CRC64;
     MAECSGLQFV SPYAFEAMQK VDVVRLAALS DPELRLLLPC LVRMALCAPA DQSQSWAQDK
     KLILRLLSGV EAVNSIVALL SVDFHALEQD ASKEQQLRHK LGGGSGESIL VSQLQHGLTL
     EFEHSDSPRR LRLVLSELLA IMNKVSESNG EFFLKSSELF ESPVYLEEAA DVLCILQAEL
     PSLLPIVDVA EALLHVKNGA WFLCLLVANV PDSFNEVCRG LIKNGERQDE ESVGGRRRTE
     ALRHLCKMNP SQALRVRGMV VEECHLPGLG VALTLDHTKN ESSDDGVSDL VCFVSGLLLG
     TNAKVRTWFG TFIRNGQQRK RDNISSVLWQ MRRQLLLELM GILPTVRSTH IVEEADVDTE
     PNVSVYSGLK EEHVVKASAL LRLYCALMGI AGLKPTDEEA EQLLQLMTSR PPATPAGVRF
     VSLSFCMLLA FSTLVSTPEQ EQLMVMWLSW MIKEEAYFES ISGVSASFGE MLLLVAMYFH
     SNQLSAIIDL VCSTLGMKIV IKPSSLSRMK TIFTQEIFTE QVVTAHAVRV PVTGSLSANI
     TGFLPIHCIY QLLRSRSFTK HKVSIKDWIY RQLCETTTPL HPQLLPLIDV YINSILTPAS
     KSNPEATNQP VTEQEILNVF QGLTGGENTR PAQRYSITTQ LLVLYYVLSY EEALLANTKI
     LAAMQRKPKS YSSALMDQIP IKYLIRQAQG LQQELGGLHS ALLRLLATNY PHLCIVEDWI
     CEEQITGTDA LLRRMLLTTI AKNHSPKQLQ EAFSMLPGNH TQLMQILEHL TLLSAGELIP
     YAEVLTSNMN CLLNAGVPRR ILQTVNKLWM VLNTVMPRRL WVMTVNALQP SVKIVRQQKY
     TQNDLMIDPL IVLRCDQRVH RSPPLMDITL HMLNGYLLAS KAYLNAHLKE TAEQDIRPSQ
     NNAMGPETPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE EEKAQSSSTY SLLKSVQSTT
     SPKSSDVEEE EDSLLCNLRE VQCLICCLLH QMYIADPNIV KLVHFQGYPC ELLALTVAGI
     PSMHICLDFI PELIAQPELE KQIFAIQLLS FLCIQYALPK SLSVARLAIN VMGTLLTVLT
     QSKRYAFFMP TLPCLVSFCQ AFPPLYEDIM SLLIQIGQVC ASDVATQTRD FDPIITRLQQ
     LKERPNEVSG LCKDSPYKSC SRDITSVDPD VQLCQCVEST IIEIINMSVS GV