ID   INT2_DICDI              Reviewed;        1362 AA.
AC   Q55CB6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Integrator complex subunit 2 homolog;
GN   Name=ints2; ORFNames=DDB_G0271040;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72870.1; -; Genomic_DNA.
DR   RefSeq; XP_646565.1; XM_641473.1.
DR   AlphaFoldDB; Q55CB6; -.
DR   SMR; Q55CB6; -.
DR   STRING; 44689.DDB0234072; -.
DR   PaxDb; Q55CB6; -.
DR   EnsemblProtists; EAL72870; EAL72870; DDB_G0271040.
DR   GeneID; 8617533; -.
DR   KEGG; ddi:DDB_G0271040; -.
DR   dictyBase; DDB_G0271040; ints2.
DR   eggNOG; ENOG502QSP2; Eukaryota.
DR   HOGENOM; CLU_007707_0_0_1; -.
DR   InParanoid; Q55CB6; -.
DR   OMA; SRTFLKH; -.
DR   PhylomeDB; Q55CB6; -.
DR   PRO; PR:Q55CB6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR026236; Int2_metazoa.
DR   InterPro; IPR029321; INTS2.
DR   PANTHER; PTHR28608; PTHR28608; 1.
DR   Pfam; PF14750; INTS2; 2.
DR   PRINTS; PR02105; INTSUBUNIT2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1362
FT                   /note="Integrator complex subunit 2 homolog"
FT                   /id="PRO_0000344374"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..660
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          928..963
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..944
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1362 AA;  155569 MW;  C57946A4A7F55952 CRC64;
     MITSNNNNKN NNKKDVEMKS NEEEGDEIFF SILSGDTNNL FKFLNNNNSN NNNNNNNNNI
     NNSIDIYLPY IIVGILEKNK DLLDEDENLK KLFYSPIYSK SIHNINQYQS LNFDHINEFI
     KDQVRIRKKL NHVNQDKKDT YLDNIDNPKY QFENGDKEVK MKLVLSDIIA LLEFSEMQQS
     LTISKETKYD APFIDTPIYN NELNLIFPII CYKCLKHIDF NKLTLSILFL NQANYLIKLL
     LSNNPNEFNE IIEIVISSIG LIGVEKVKRV LLEICKLSKY CSRFIRTELI NRQMLPDLVL
     LITSQFVKDE IDLLSNIISN RIENQWLKEY ISQKDQFSTF NEIRDSLFST LELISKEISS
     NSNNNSNNLE HSFIVKSIIR LYCGFSGLLG IKMNQQEISI SLSFIEKSIF KNYSKIFLCF
     LLVCEGLVKT IHPKKELVGY LNHLCKVGNC DELLLLISIY FHTHQLQNIA LLVKNILGFR
     PSIHTESLNQ IGEILTKEIY TESLVAKRAQ QLPIIEKLNT NHQNISIVCV YHLLSERIFE
     KYETDVGNWC WSQLTKSSTP IHYLLPSLLD QLCKNIIEPS INNNNTSSTT SIINTSTTAA
     AASTTASNAN TTAATTTTTT AATITTATTT GTTTGISPSS STTTTSSTGG ATSTSISSPN
     STSLGNSYLF STFSSTSSSS SSGLPFYMKR ISESIIMNSI QQSQSNLSVQ ILIIYFVLRY
     NDSVIKFKSE QKGKPIQFLI ETTQLREYNI EFLSKLPIQN CINVILSNQS DYFYIIPPFL
     YLILSQFPQF FNINLLLLEE ERLLNPIEKF IYLPNFYSIN GGANNNSGGI TNEFLKDTLK
     RTLSQPTSVQ LILRYLNTLS VKELLPFTTT LLDNLLPIII KNRSLPSVSA LISPFVEIWE
     RVFPISQSSI ALKTINILTC INDDKSTNNN KDLEDYNNNN NNNNDDVKMK DKEKEDKEEE
     EEEEILLPIS NYTYTDIISD PLVIFRSHPT VFTCPPLFKI LLQILFFYMV SSKKNLQNQL
     HTSSGSGSGT TSNVTLNKQQ QEDVSTLILT QESTIIQILL EICLIDGIDT KGLNKILRNK
     NKKFKESYDP VDIEEIRCQI CSFIHQMFID KPLIIKLVHF QGYLSQLLPI TVTLIPSMHI
     CFEFIPELLA QPSLEKQIFA IQLLSYLSEK FPIPKSLKIC RQSQTRISFN LNSNTLSYDD
     RIKFLHSILP SITRITKTFP LLAEDFVSIL MEQLPNKHNY QQNLKSFISS IDFNLNSNLN
     NYTNSIYLQN NKNNNNSSNN NNSNNQNDLL NIDIDNNINS NNNNNLRNIN FKKVSNDDKS
     FFSKVSKNES WLSIKENNDP FNIPIEQEIH QAIQIIIKNL SK