ID   INT3_ANOGA              Reviewed;        1082 AA.
AC   Q7PRB8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 5.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Integrator complex subunit 3 homolog;
DE   AltName: Full=SOSS complex subunit A homolog;
GN   ORFNames=AGAP002539;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
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DR   EMBL; AAAB01008859; EAA07507.6; -; Genomic_DNA.
DR   RefSeq; XP_312400.5; XM_312400.5.
DR   AlphaFoldDB; Q7PRB8; -.
DR   SMR; Q7PRB8; -.
DR   PaxDb; Q7PRB8; -.
DR   GeneID; 1273424; -.
DR   KEGG; aga:AgaP_AGAP002539; -.
DR   CTD; 1273424; -.
DR   VEuPathDB; VectorBase:AGAP002539; -.
DR   eggNOG; KOG4262; Eukaryota.
DR   HOGENOM; CLU_007659_0_0_1; -.
DR   InParanoid; Q7PRB8; -.
DR   OMA; LCHEDNI; -.
DR   OrthoDB; 644334at2759; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   InterPro; IPR045334; INTS3.
DR   InterPro; IPR019333; INTS3_N.
DR   PANTHER; PTHR13587; PTHR13587; 1.
DR   Pfam; PF10189; Ints3_N; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1082
FT                   /note="Integrator complex subunit 3 homolog"
FT                   /id="PRO_0000385307"
FT   REGION          483..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          923..945
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1005..1082
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1082
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1082 AA;  122657 MW;  8B68FD8FF1BC6B12 CRC64;
     MDASGKGAAG FEGKLFVQTI DARDENEEKY MRAYRAFEET TAGLSDKDFH DLLSSLVSKE
     KQHEEISLAL VYIILTDPSS APKTYRDLTL LTRDGLGFVT ANLAMLVAEK YHKLTDVGRK
     QLLWLLRELI KNQVLNVDNL AWNILRQASG GDISPKNVAL IEGLLDIFTE HRAWLEKDQF
     LVGTVAYTFV RLIEDHFGPQ FVHLRNREVK FVISLIRDRF MDIIPLGREF VRLLQNVGRI
     PEFDQLWKDM LYNPKSLCPT FNGVWQLLQT RTSRRFLRGR LTPDIERKIH FLTSNVKFGN
     QKRYQDWFQE RYFNTPESQS LRCDLIRFII SAIHPTNDML CSDIIPRWAI IGWLLTSCTN
     AVTLANAKLA LFYDWLFFDP AKDNIMNVEP GILVMYHSIK NHPLVSCTLL DFLCRIMKNF
     YPKWEDRIRT GIYNSLRKIL EMKVIPNLVP LFESPKLDRE LKGMLRETFR EFCVPPNSMY
     MHPGPPQPGM ETPMMMHYPG PGGGEQVEQH PPHLMHPAAK AASTAASADD PKFSDDEDDA
     TTKPATTTTT TTTTTKTEDV SDDDDLPLAK VRLLEKPAIA KVALPDTLNG HLEEFLREKS
     VKTFEPLLQC LGSCGKAALN QEQENYLTES VISVIKQTLP DKSYFPASKT DDNLSESINY
     PLFAAYRLLY QQEDSCKKRV MALLVAIVTR VSVAGYMLLY FLKVHGKLQG RRKETAGGST
     AFKASVYGVL CDALDSVDSV DECIEKDLNL LEKHNTQMFL WILPDMYREF KQTMLNNTTV
     LRLLVGCIDA NNLGDIIYSI TQGKLILFDE DGIVEILRKS LEYETFEQVC IWQLVQAHDI
     PLETFQEIIP ELESGAHAEA LTAILLLLRA EKPTTELVRL LLSRETESKH RGDPFVTSVL
     RYWCQEFEEK LSELIAALLT SKYPSNSPNK RKRPSKSAQQ NTAPTSEQLL NHLEHFRRSC
     RHGNGTGTGL FVQNDMQRAL QQAFTHSSES QRKQFSDLFA LAAEDETSTT VGRRGTSSRG
     RKAPSNKKET AAEKAAAAAA AAHANNSKKA AEASAKFSDD SSDEDWSKQK ASKRRKTLSD
     SD