INT3_DICDI
ID INT3_DICDI Reviewed; 1520 AA.
AC Q55EZ4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Integrator complex subunit 3 homolog;
DE AltName: Full=SOSS complex subunit A homolog;
GN Name=ints3; ORFNames=DDB_G0268706;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
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DR EMBL; AAFI02000004; EAL72942.1; -; Genomic_DNA.
DR RefSeq; XP_646876.1; XM_641784.1.
DR AlphaFoldDB; Q55EZ4; -.
DR SMR; Q55EZ4; -.
DR STRING; 44689.DDB0234074; -.
DR PaxDb; Q55EZ4; -.
DR EnsemblProtists; EAL72942; EAL72942; DDB_G0268706.
DR GeneID; 8616559; -.
DR KEGG; ddi:DDB_G0268706; -.
DR dictyBase; DDB_G0268706; ints3.
DR eggNOG; KOG4262; Eukaryota.
DR HOGENOM; CLU_247789_0_0_1; -.
DR InParanoid; Q55EZ4; -.
DR OMA; LWRDINT; -.
DR PRO; PR:Q55EZ4; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR045334; INTS3.
DR InterPro; IPR019333; INTS3_N.
DR PANTHER; PTHR13587; PTHR13587; 1.
DR Pfam; PF10189; Ints3_N; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..1520
FT /note="Integrator complex subunit 3 homolog"
FT /id="PRO_0000344375"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..920
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 173734 MW; D2C7B944DBE96BA1 CRC64;
MMNQQQQQQQ PPTTSPTQQQ QLTQLQTHQY FQNKFKLFYK RELDEADPLE IYWRECYDKI
ELLLLNSSEA EINNYLIEKS ASVESSGNND QSNKFHTEVT IGFLYAILLG SPQNIALSHQ
YFKSLTFFTK DSLALFCSLL KKLIADKFQK LNDTPRQQVV WIINELIATN HQDCESVTSI
ILRHIYGGNF TSKNLSLSHS MLNMFLTHRQ WLNSRPLLIP TILYNFLRLI QDHISRPQGL
HNPTHLKDEI NFCLDLLKNK FQECLVIGRD LIRLLQYLST KTIEFEQLWK DLNSKPTTFA
PGYYDIIQSM KTPTPKHFLQ SRLSPEMELQ VLYILKEVKF GNQKRYQQWF VTKYLVTPES
ESLIPDIIRY ICCVYHPPNH VLCSDIVPRW AIIGWLLKHC KSDAWRNYSK LSLFLDWLYF
EPKIDSIMNI EPAILLMAGS VKKYADMTID LVEFIVGTLL DSYDIQRKDA IRQGIHNSFA
TVLEKGVVQS LSHVFPPDSL GPSLFEKVKH YFHQFLTNSP IHQLHSQQQQ LQQQQLQQPQ
QPQQQQQPPQ YKPYPQQPIN KQLPLQMSPQ QQSQQQLQQQ QLQQQLQQQQ QQQQPPQQPP
PQQQPQQQPP QQQPQQQPQQ QQPQLNISTG NLPNIQQPMV KSPPLSSNTL VSPTSSSSPT
SSNLPTNNSR VLNKSGVDIH HVSNLSPQVI SQKPQSQQTP SLHSSSQSVL QQKSPPLKET
SLFEQQQPSQ QLPSQIVKNS PPNLSMTNEN ISNPPPPPHA KISSDHASPL INSSNSNITT
PNPDSQSQIP IPPPISQSPS TKNIDVIMSE LNDEPPKLSK SSPTQSNIIV PPPTHKPPQT
TISSSSPLLQ PQTQPQPQTQ PQPQTLQQST TPSLSSSSTP TIPISPPLLP TQLEIDIQPP
PPPPSSQPLQ PPPPPPPSQN IKDETLNSLI ELNSSIKLDE EIKMEIPDIL LTIGSKPQFQ
PTNITITLGS ILSNFNEKIS KQPNITLQNE LTDSLTQYLS QVLKPELQID LSTTPSLLSL
FCNFQVIHHI FRATFSPTDN SITTTTTTTA AATTTTTTTP TIVKPMFNIL KELYKIYPSI
GFKIMIWSII TSPGGLNITN NGCTYIYPDI ECDNSFSNSD DNESTNNNNN GVEQKPQQQQ
QQQQQQQINE NTHNNNNNNN NNNNNNNNNN NENNITNNSQ NITIKEESIF KIEKLLESVQ
DSNGNRNILG NYLNFHSNLL GGQPPPPPPP QQPNKIVEQI ISDCIEANNV GAFNYLVPIL
YKSFSNLLVG NSDFLYLVLS CINPRQHFRI CNKISMGEFR VFGNEMKSLI SQSFKWESFE
QNYLWQMLIA EDSVYSGMIV KEYPFIISKL DPYNNSEVLQ NLTITLKETK FYDFNIFSET
LLLNDYFYTF VFCLFSFWLK NNTTQTFNYI NQIFDFYLSN NNNNNNNNRK LVERILYFYN
IFLKKYGEER IKWSDMIDSD RVSKVLQRST NSNLFQKYSN LGSLVLPSQS SNIKNDNNPT
LSKHQNSDDD SNPKKRFRKE
