ID   INT3_DROGR              Reviewed;        1083 AA.
AC   B4JPR2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Integrator complex subunit 3 homolog;
DE   AltName: Full=SOSS complex subunit A homolog;
GN   Name=IntS3; ORFNames=GH13349;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
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DR   EMBL; CH916372; EDV98892.1; -; Genomic_DNA.
DR   RefSeq; XP_001992967.1; XM_001992931.1.
DR   AlphaFoldDB; B4JPR2; -.
DR   SMR; B4JPR2; -.
DR   STRING; 7222.FBpp0147255; -.
DR   PRIDE; B4JPR2; -.
DR   EnsemblMetazoa; FBtr0148763; FBpp0147255; FBgn0120825.
DR   GeneID; 6566426; -.
DR   KEGG; dgr:6566426; -.
DR   eggNOG; KOG4262; Eukaryota.
DR   HOGENOM; CLU_007659_0_0_1; -.
DR   InParanoid; B4JPR2; -.
DR   OMA; LCHEDNI; -.
DR   PhylomeDB; B4JPR2; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   InterPro; IPR045334; INTS3.
DR   InterPro; IPR019333; INTS3_N.
DR   PANTHER; PTHR13587; PTHR13587; 1.
DR   Pfam; PF10189; Ints3_N; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1083
FT                   /note="Integrator complex subunit 3 homolog"
FT                   /id="PRO_0000385309"
FT   REGION          551..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          929..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1014..1083
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..568
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1040..1054
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1055..1083
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1053
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1054
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1058
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1059
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1083 AA;  124901 MW;  9B29E4870D21B3DC CRC64;
     MEQQQQQQQQ QKSVAHISKL FVCTAVDCKD EIEEKFERSY VSLQQQIAGL SDKEMHDILT
     QFVCKEKQHE EISIGFLYII LTDPAMAPKT YRDITLVSRD GMNVIVANLT LLVAEKYAKL
     TETARRQLIW VLREFVKHQV LSVENVIWNC LRQAGGGDVS HKNLYLVESL LDIFIEYRAW
     LETNPFLVQS SVYSFVRLIE DHANPALISL RQKEVKFTIS LIRDRFHDII PLGRDFVRLL
     QNVARIPEFE LLWRDILYNP KSLHPTFNGI WHLLQIRTSR RFLQCRLLPE MERKLHFLAS
     SVKFGNQKRY QDWFQDKYFA TPESHSLRSD LIRFIINVIH PTNDMLCSDI IPRWAIIGWL
     ISSCTNPIAS ANAKLSLFYD WLFFDPAKDN IMNIEPGILV MYHSIRNHPF VSSTLLDFLC
     RITKNFYVKN EDRIRLGVYN SLKLILDKQV IPNLHPLFES PKLDRELRNL IRENFREFVT
     PVANMPQSMY PATHTIQAPI FKKEADQRLM QGEIMDAGGG GAFVASSGTN MLVDDDNKIA
     IAPLESMERE NEAVFSDDEN LPSTSKNEEN TDDDDDLPLS KVRLKEKPVP EKVELPDAIA
     ESFEIFVTKR NSFTWEAFLK DFRTLPASAL DETQLNYVIS NTVLILRETL PQQNVFSESK
     TEEKYLAKSI SYPLYGLFRF LYENEDKSKK PFQTLLSEIC GRLTETGYLL LYFMKIHCKL
     QTRKNAQQSY QFKTTVYRQI CEATDEKIGV CLVRDLDLLE KENTTIYLWL LPDIYREFKT
     IAINNTELLR ITLRCIDAKN VRDIMYSIAQ GKLTIFKQDG LLDCIRDSLE YETYEQFCLW
     QLIQAHDVPL KCIQDLLPEL EAANHPEALS HLLLLLKNEE PTNEIIRLLL SREAKSRGDP
     FVTSALRFWC QRCEEKLSEI IASLLTSKYP SSSPNKRKRP SKGSSAASST PSADHVLNHL
     EHYRRSCRHG TGTGLYVHDM MQRALQSAYS HSNESTKKQF SDLFALAAED ETTAVGRRGG
     SGRGRKQPVG KKDSSNHSAS SKKNSDVVKT IYSSDENSSE EDWSKHKVTQ PAKKRKKAIN
     DSD