ID   INT3_DROSE              Reviewed;        1068 AA.
AC   B4IMI7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Integrator complex subunit 3 homolog;
DE   AltName: Full=SOSS complex subunit A homolog;
GN   Name=IntS3; ORFNames=GM26749;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH481016; EDW48749.1; -; Genomic_DNA.
DR   RefSeq; XP_002044947.1; XM_002044911.1.
DR   AlphaFoldDB; B4IMI7; -.
DR   SMR; B4IMI7; -.
DR   STRING; 7238.B4IMI7; -.
DR   EnsemblMetazoa; FBtr0209734; FBpp0208226; FBgn0181602.
DR   GeneID; 6620745; -.
DR   KEGG; dse:6620745; -.
DR   HOGENOM; CLU_007659_0_0_1; -.
DR   OMA; LCHEDNI; -.
DR   PhylomeDB; B4IMI7; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   InterPro; IPR045334; INTS3.
DR   InterPro; IPR019333; INTS3_N.
DR   PANTHER; PTHR13587; PTHR13587; 1.
DR   Pfam; PF10189; Ints3_N; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1068
FT                   /note="Integrator complex subunit 3 homolog"
FT                   /id="PRO_0000385312"
FT   REGION          916..939
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1001..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1040..1068
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1038
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1039
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1043
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1044
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1068 AA;  123781 MW;  775BAA1A0E48EC77 CRC64;
     MEQQQSKNNA HVSKLFVCTA VDCKDDIEEK FERSFLTLQM QISGLSDKEM HDMLSQAVCK
     EKQHEDISIG FLYIMLTDPS MASKTYRDVT LVSRDGMNGI VTNLTFLVAE KYTKLTEVAR
     RQLIWLLREF VKHQVLSVEN VIWNCLRQAG GGDVSSRNLF LIESLLDIFI EFRTWLESNP
     FLVQSTVYSF VRLIEDHANP ALLSLRQKEV KFTISLIRER FHDIIPLGRD FVRLLQNVAR
     IPEFEQLWRD ILFNPKMLHQ TFNGIWQLLH IRTSRRFLQC RLLPEMERKI SFLASSVKFG
     NQKRYQDWFQ DKYFATPESH SLRSDLIRFI INVIHPTNDM LCSDIIPRWA IIGWLISSCT
     NPIASANAKL SLFYDWLFFD PAKDNIMNIE PGILVMYHSI RNHPFVSSTL LDFLCRITKN
     FFVKHEDKIR IGVYNSLKLI LEKQVIPNLQ PLFESPKLDR ELRNLIRDNF REFLSPPANL
     GQLLYTSLHP VQGHILKIES DQRILHCENV DLHETGLINI SGTVDEDKKI SLVPTDQEIE
     SVFSGETAEN LRRVHNIEDN TDDDDDLPLS EVRLKEKPKV ELAEAIAESF DAFVTKRNSY
     TWEAFLKDFR PLPASAFEEF QLNYVISNTV LILRETLPQQ NIFSESKTEE KHLAKSISYP
     LYGLFRFLYE NDEKSKKPFQ TLLSEICEGI PEIGYLLLYF MKIYCKLQTR KNSQQSYQFK
     TTIYRQICDA ADEKIGHCLL RDLDLLEKEN TNIFLWLLPD IYREFKSIAT NNTDILRITL
     RCIDAKNVRD ILYSVAQGKL TIFKQDGLID CIRQSLEFET YEQFCLWQIV QAHDVPLRCI
     QDILPELEAG SHPEALSHFL LLLKNEEPTN EIIRLMLSRE SKSKGDPFVT SVLRFWCQRY
     EEKLSEIIAS LLTSKYPSSS PNKRKRPPKG ISVSTSTPSA DQVLNHLEHY RRSCRHGTGT
     GLYVHDMMQR ALQSAYSHSN DSTKKQFCDL FALAAEEDTT VGRRGGSGRG RKQPGSKKDV
     NNHGTSKKNA EMVKTIYSSD DNSSEEDWSK SKILQTAKRR KKANNDSD