ID   INT3_DROWI              Reviewed;        1086 AA.
AC   B4NP05;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Integrator complex subunit 3 homolog;
DE   AltName: Full=SOSS complex subunit A homolog;
GN   Name=IntS3; ORFNames=GK23434;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
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DR   EMBL; CH964289; EDW86094.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4NP05; -.
DR   SMR; B4NP05; -.
DR   STRING; 7260.FBpp0252577; -.
DR   EnsemblMetazoa; FBtr0415810; FBpp0374012; FBgn0225396.
DR   EnsemblMetazoa; FBtr0417925; FBpp0376083; FBgn0279753.
DR   eggNOG; KOG4262; Eukaryota.
DR   HOGENOM; CLU_007659_0_0_1; -.
DR   InParanoid; B4NP05; -.
DR   OMA; LCHEDNI; -.
DR   OrthoDB; 644334at2759; -.
DR   PhylomeDB; B4NP05; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   InterPro; IPR045334; INTS3.
DR   InterPro; IPR019333; INTS3_N.
DR   PANTHER; PTHR13587; PTHR13587; 1.
DR   Pfam; PF10189; Ints3_N; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1086
FT                   /note="Integrator complex subunit 3 homolog"
FT                   /id="PRO_0000385314"
FT   REGION          558..581
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          932..955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1015..1086
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..581
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1043..1057
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1058..1086
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1056
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1057
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1061
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1062
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1086 AA;  125683 MW;  711146451796874A CRC64;
     MEQQPHQSKS ASYISKLFVC TSVDCKDEIE EKFERSFVNL QQQISGLGDK EMHDILSQIA
     CKDKQHDEMS IGLLYIMLTD PIMAPKTYRD ITLVSRDGMS VIVANLTLLV AEKYSKLTEG
     ACRQIIWVLR EFVKHQVLSV ENVIWNCLRQ AGGGDVSHKN LYLVENLLDI FIEYRNWLET
     NPFLVQSIVY SYVRLIEDHS NPALASLRQK EVNFTISLIR DRFQDVIPLG RDFVRLLQNV
     ARIPEFEQLW RDVLYNPKSL HPTFNGIWQL LQIRTSRRFL QCRLLPEMER KLHFLASSVK
     FGNQKRYQDW FQDKYFSTPE SHSLRSDLIR FIINVIHPTN DMLCSDIIPR WAIIGWLISS
     CTNPIASANA KLSLFYDWLF FDPTKDNIMN IEPGILVMYH SIRNHPFVSS TLLDFLCRIT
     KNFYVKYEDK IRMGVYNSLK LILDKQVIPN LQPLFESPKL DRELRNLIRD NFREFVSPAA
     TNSLSQPLYP TICSIQAPIF KKETDQRIMQ CSQDHFEIGE ATFNANSDTI VSLLDGENKI
     VVIPTETLTT DNEVVFSDED VEGVGRPNKN EENTDDDDDL PLSKVRLKEK PFTEKIELPQ
     TIAESFETFV AKRNSFTWES FLKDFRTLPA CTLEEGQLNY VISNAVLVLR DTLPQNHIFS
     ESKTDEKFLA KSISYPLYGL FRFLYENEDK SKKPFQTMLS EICERIPEIG YLLLYFMKIH
     CKLQTRKNSQ HPYQFKTSVY RQICEATDDK IVNCLVRDLD LLEKENTAIY LWLLPDIYRE
     FKSIAINNNE ILRITLRCVD AKNVRDIIYS VAQGKLAIFK HDCIIECIRE SLDYETYEQF
     CLWQLIQAHD VPLKSIQDLL PELEAANHPE ALSHMLLLLK NEEPTNEIIR LMLSREAKAR
     GDSFVTSALR FWCQRYEEKL SEIIASLLTS KYPSSSPNKR KRPTKSSSAS SSIPSADQVL
     NHLEHYRRSC RHGTGTGLYV HDMMQRALQS AYSHSNDSTK KQFSDLFALA AEDETSAVGR
     RGGSGRGRKQ PLNKKDSNIH NTGNKKNSEI LKTVYSSDDN SSEEDWSKHK ISQAAKKRKK
     NIPDSE