ID   INT3_DROYA              Reviewed;        1072 AA.
AC   B4ISV0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Integrator complex subunit 3 homolog;
DE   AltName: Full=SOSS complex subunit A homolog;
GN   Name=IntS3; ORFNames=GE11342;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the Integrator subunit 3 family. {ECO:0000305}.
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DR   EMBL; CH891608; EDW99532.1; -; Genomic_DNA.
DR   RefSeq; XP_002086062.2; XM_002086026.2.
DR   RefSeq; XP_015045263.1; XM_015189777.1.
DR   AlphaFoldDB; B4ISV0; -.
DR   SMR; B4ISV0; -.
DR   STRING; 7245.FBpp0256352; -.
DR   PRIDE; B4ISV0; -.
DR   EnsemblMetazoa; FBtr0257860; FBpp0256352; FBgn0229156.
DR   GeneID; 6539157; -.
DR   KEGG; dya:Dyak_GE11342; -.
DR   eggNOG; KOG4262; Eukaryota.
DR   HOGENOM; CLU_007659_0_0_1; -.
DR   OMA; LCHEDNI; -.
DR   OrthoDB; 644334at2759; -.
DR   PhylomeDB; B4ISV0; -.
DR   Proteomes; UP000002282; Unassembled WGS sequence.
DR   InterPro; IPR045334; INTS3.
DR   InterPro; IPR019333; INTS3_N.
DR   PANTHER; PTHR13587; PTHR13587; 1.
DR   Pfam; PF10189; Ints3_N; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           1..1072
FT                   /note="Integrator complex subunit 3 homolog"
FT                   /id="PRO_0000385315"
FT   REGION          920..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1002..1072
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1044..1072
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1042
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1043
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1047
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1048
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1072 AA;  124303 MW;  E1BB7E804982FF4E CRC64;
     MEQQQSKNIV HVSKLFVCTA VDCKDDIEEK FERSFVTLQM QISGLSDKEM HDMLSQAVCK
     DKQHEEISIG FLYIMLTDPS MAPKTYRDVT LVSRDGMNGI VTNLTFLVAE KYTKLTEVAR
     RQLIWLLREF VKHQVLSVEN VIWNCLRQAG GGDVSSRNLF LIESLLDIFI EFRTWLEGNP
     FLVQSTVYSF VRLIEDHANP ALMSLRQKEV KFTISLIRER FHDIIPLGRD FVRLLQNVAR
     IPEFEQLWRD LIFNPKILHQ TFNGIWQLLH IRTSRRFLQC RLLPEMERKI SFLASSVKFG
     NQKRYQDWFQ EKYFATPESH SLRSDLIRFI INVIHPTNDM LCSDIIPRWA IIGWLISSCT
     NPIASANAKL SLFYDWLFFD PAKDNIMNIE PGILVMYHSI RNHPFVSSTL LDFLCRITKN
     FFVKHEDKIR IGVYNSLKLI LEKQVIPNLQ PLFESPKLDR ELRNLIRDNF REFLSPSANL
     GQLLYPSMHP AQGYIIKKES DQRILHCENM DLHETGLINT SGSNISMLDE DIKISLVPTD
     LEIESVFSDE TAENLKRVHN IEENTDDDDD LPLSKVRLKE KPRVELAESI AESFDAFVTK
     RNSYTWEAFL KDFRPLPASA FEEFQLNYVI SNTVLILRET LPQQNIFSES KTEEKHLAKS
     ISYPLYGLFR FLYENDEKSK KPFQILLSEI CEGIPEIGYL LLYFMKIYCK LQTRKNSQHS
     YQFKTTIYRQ ICDAVDEKIG NCLIRDLDLL EKENTNIFLW LLPDIYREFK SIATNNTDLL
     RITLRCIDAK NVRDILYSVA QGKLTIFKQD GLIDCIRESL DFETYEQFCL WQIVQAHDVP
     LRCIQDLLPE LEAGSHPEAL SHFLLLLKNE EPTNEIIRLM LSRETKSKGD PFVTSALRFW
     CQRYEEKLSE IIASLLTSKY PSSSPNKRKR PPKGISVSTS TPSADQVLNH LEHYRRSCRH
     GTGTGLYVHD MMQRALQSAY SHSNDSTKKQ FSDLFALAAE EDTTVGRRGG SGRGRKQPGS
     KKDVSNHGTS KKNAEMVKTI YSSDENSSEE DWSKSKMTQT AKRRKKANND SD