ID   INT4_DICDI              Reviewed;        1233 AA.
AC   Q54LH5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Integrator complex subunit 4 homolog;
GN   Name=ints4; ORFNames=DDB_G0286633;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000089; EAL64072.1; -; Genomic_DNA.
DR   RefSeq; XP_637586.1; XM_632494.1.
DR   AlphaFoldDB; Q54LH5; -.
DR   STRING; 44689.DDB0234080; -.
DR   PaxDb; Q54LH5; -.
DR   EnsemblProtists; EAL64072; EAL64072; DDB_G0286633.
DR   GeneID; 8625726; -.
DR   KEGG; ddi:DDB_G0286633; -.
DR   dictyBase; DDB_G0286633; ints4.
DR   eggNOG; KOG2259; Eukaryota.
DR   HOGENOM; CLU_267504_0_0_1; -.
DR   InParanoid; Q54LH5; -.
DR   OMA; CIKLIWI; -.
DR   PRO; PR:Q54LH5; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..1233
FT                   /note="Integrator complex subunit 4 homolog"
FT                   /id="PRO_0000344376"
FT   REPEAT          236..273
FT                   /note="HEAT 1"
FT   REPEAT          275..310
FT                   /note="HEAT 2"
FT   REPEAT          487..524
FT                   /note="HEAT 3"
FT   REPEAT          525..561
FT                   /note="HEAT 4"
FT   REPEAT          563..597
FT                   /note="HEAT 5"
FT   REGION          426..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          767..796
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          993..1057
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1014..1046
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1233 AA;  141988 MW;  330219236A04458A CRC64;
     MNKKSHQQQV LQQQQQQQQQ QFQQQHFQQQ QQQQQFQQQQ QQQQQLQQQQ LQQQQQQQIQ
     QQQQIQQQQQ QQQQQQQQIQ QQQQPQQIQQ PQQQLPNFSV PIINQSIISN IKLYSTFETL
     LLSLSSTDTR EQTKAIIYLS SLTINNKSNG IDLVYCIQKQ LVVEAHNHIK VLLINLLGDI
     SLDPFIDSFH ILNKLLYLIR NEKSKKVLSS CLININKISK SLTFSKGNDV NSSSSSLINQ
     IIEYIEPLLH STSPLVRRET IVLLGSIVKN LDKESEEIQI LLLNYLKDTD FRVREASLKS
     LSVIFQRGAS LSVNKLYQSI ILLLLDSFEQ VRLECIKLIW IFGNIYPNHI VVSGGTKIRL
     VDDVFKKICN AVNDSSVIVR NCACKLLGCT YDVSLNYLIQ TLSKEVMVWG KGKQYQIGHS
     SITKQRLQQK QQQQQQQQQQ QQQQPPQQQP SQQPNQQPNQ QQTNVSGTHI ATPEGDFDVV
     GSDSLNILES GVIGAFIQGL EDEFYEVRSS AIDSMCELSV RNDEFAQKNI DFLVDIFNDE
     IESVRINSIN SLRKIGNNVV IKEEQLHIIL ANLESSSKEE RQSLHRLLTS IHLSNYSCLH
     ATTQALLMNL SRYPYDIHSI FETLKIIGQT NPFTEFIVDD LLRIDPKFAS VEPNMDDIFY
     VAVMVLVLNS CIKNRNILSL LPSFSFQHHL YFKDKYPKYF PQNLQKDSNI ILAPTLKYSS
     VVNNNNNKNN NNNTTTTSII NDNGEINQFL NLTLSLLYGD NNNIINNNNT NNNNNNNNNN
     NNNNNNNNNN NNDENDENLN YGFQRLFLNQ KKEIQLNKLF QECKRNFKRI SSICLSLKPT
     SDFYNKYLKI LTTIVSSSRR FKTITTSNQL NHLLYKLNHK FIGVDNNCKL ILMEIGIYSF
     IIEILSTITL STSSPPTTTT TTSSTSLFTS INSTPIELSN DQINQLTKKL NEYFKFSNDF
     KLEISTSIKS LLDLFNIKNN NINNNNNIIN KKDKKLKENE ENEENEENEN NENENEKENG
     KNKEKEKNEN DNENENENER PSKIQKTTSE LIKTTTTTST STSTLIHYNL IEWTDNYIPP
     ILKISNLIKK KSVDVILPIP NDKPIEFLDI FPLKLMINAK IENIRNLDSL FIQSTWQSIH
     TGQLNSQIHI IPKSAFTPTK PLSYNISCSI YLSLQNIRHN RLSSKESIPL RISIVEQFLN
     NNNNNNVTII PLSKFVIFNI LPVDNVNLLP NLI