ID   INT4_XENLA              Reviewed;         969 AA.
AC   Q68F70;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Integrator complex subunit 4;
DE            Short=Int4;
GN   Name=ints4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q96HW7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96HW7}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 4 family. {ECO:0000305}.
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DR   EMBL; BC079973; AAH79973.1; -; mRNA.
DR   RefSeq; NP_001087469.1; NM_001094000.1.
DR   AlphaFoldDB; Q68F70; -.
DR   SMR; Q68F70; -.
DR   BioGRID; 104153; 1.
DR   MaxQB; Q68F70; -.
DR   DNASU; 447293; -.
DR   GeneID; 447293; -.
DR   KEGG; xla:447293; -.
DR   CTD; 447293; -.
DR   Xenbase; XB-GENE-5841134; ints4.L.
DR   OrthoDB; 256550at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447293; Expressed in ovary and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..969
FT                   /note="Integrator complex subunit 4"
FT                   /id="PRO_0000259540"
FT   REPEAT          68..107
FT                   /note="HEAT 1"
FT   REPEAT          147..185
FT                   /note="HEAT 2"
FT   REPEAT          192..230
FT                   /note="HEAT 3"
FT   REPEAT          231..265
FT                   /note="HEAT 4"
FT   REPEAT          279..315
FT                   /note="HEAT 5"
FT   REPEAT          371..407
FT                   /note="HEAT 6"
FT   REPEAT          408..446
FT                   /note="HEAT 7"
FT   REPEAT          448..486
FT                   /note="HEAT 8"
FT   REGION          928..950
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   969 AA;  109256 MW;  3F27196C3CE4C54A CRC64;
     MAAHLKKRVY EEFTRVVQQQ PLEEPSAKKL RLTKPSKSAA LHIDLCKATS PADALQYLLQ
     FARKPVEAES VEGVVRILLE HYYKENDTSV RLKIASLLGL LSKTAGFCPD SIVDDVINTL
     QNEKSHQVLA QLLDTLLEIG LKLLDIVSHR MRLVDVACKH LSDTSHGVRN KCLQLLGCLG
     SVEASPAKEV ENAVAKDVQK IIGDYFIDQD PRVRTAAIKA MLQLHERGLK LQQAMYNQAC
     KLLTDDYEQV RSAAVELSWV LSQLYSESIV PIPSSNEEIR LVDDAFGKVC HMVSDGSWVV
     RVQACKLLGS MLQVSPHFLE QTLDKKLMSD LRRKRTAHER AKELYSSGEF SSGRKWGDDA
     PKEELDTGAV NLIDSGACGA FVHGLEDEMY EVRIAAVESL CLLARSSAPF AEKCLDFLVD
     MFNDEIEEVR LQSIHTMRKI SDNITLREDQ LDTVLAVLED KSRDIREALH ELLCCTNVST
     KECIQLALVE LLKNLSKYPT DRESIWKCLK FLGSRHPTLV LSLVPELLST HPFFDTPEPD
     MDDPAYIAVL VLIFNAAKCC PTMPALFSDH TFRHYTYLRD SLSHLVPALN LPSVRWSWIP
     DVITEAPPED PSQQFLQLSL ERVHNLQHLG SQGTQELLEF TIRDLQRIGE LQSDLAGMAD
     FSATYLRCHL LLTKALNEKL WNLAAPLFLK NSLTTNAVKQ ILEETYKMEF MYSGLETRQV
     AIIHHMRLQA KALQLLVTAR TTKGAEPLFG MCEEFLQEVD FFQRCFISEL PHMQDSFVDK
     LLDLVPRLVN SKPLEMVKIL QTTLRQCTFL RLTLPEQIHR ASSHIIEPAE ESDNPIRFTS
     GLVVALDVDA TLEHVQEPQS TVKVQVVYPD GQVQIIHPKP ADFRNPGPGR HRLITQVYLS
     HTAWTEPCQI EVRLLLAYSS SRSKVMSRAS NSTWGESTET VPSTESSTEG TIPFSKPVKV
     FLMPKPARR