INT5_DICDI
ID INT5_DICDI Reviewed; 1563 AA.
AC Q54X25;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Integrator complex subunit 5-like protein;
GN ORFNames=DDB_G0279251;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be a component of the Integrator complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 5 family. {ECO:0000305}.
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DR EMBL; AAFI02000030; EAL67774.1; -; Genomic_DNA.
DR RefSeq; XP_641752.1; XM_636660.1.
DR AlphaFoldDB; Q54X25; -.
DR SMR; Q54X25; -.
DR STRING; 44689.DDB0234101; -.
DR PaxDb; Q54X25; -.
DR PRIDE; Q54X25; -.
DR EnsemblProtists; EAL67774; EAL67774; DDB_G0279251.
DR GeneID; 8621950; -.
DR KEGG; ddi:DDB_G0279251; -.
DR dictyBase; DDB_G0279251; -.
DR eggNOG; ENOG502RAR0; Eukaryota.
DR HOGENOM; CLU_245839_0_0_1; -.
DR InParanoid; Q54X25; -.
DR OMA; YILTSIW; -.
DR PRO; PR:Q54X25; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR InterPro; IPR040316; INTS5.
DR InterPro; IPR029444; INTS5_C.
DR PANTHER; PTHR31697; PTHR31697; 2.
DR Pfam; PF14838; INTS5_C; 1.
PE 3: Inferred from homology;
KW Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1563
FT /note="Integrator complex subunit 5-like protein"
FT /id="PRO_0000344377"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 877..897
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1303
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1563 AA; 180165 MW; ACCC952AE734E41B CRC64;
MKEEETIEIS EKEKDKERND NQDTLTISWI EDWRNEETAT KNENNKNNNS DGDSDDDDYY
DDDEEIKNSR YNLFLEKILT LESNSNLKNI LSLNINFKKD NKKSKETDTA ATTTTTTTTT
TTTTTTTTPT ATANKKYIRT NNLLNNNNSS SSSSSNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNGENITYIT SPLSNESLES TEECCFFLVH LPITKDLIFN
QFTCLLIHLF QIEYNNTIII NNATSSSSVN SLNRSYNNSN NNNNNNYNSY NNRGNNYNNN
NQQQQQQQNP NLKIRDLEGY QDCSHLKKLC LTIHDYLTQL LQRNPLIWYD SIINWSLSTL
TIITRLLIIL KNNKSQQQQQ QQQQQQQQQQ QQQQQQQQTK NKTQFPPPPP PPLRQPITPI
SAMVRERLDF YSFRSLLSLV LHLTRIFSIE TFIEKSNVTQ FLDITSKSSS SSSSSSSSSS
SSSSSSSSSS SSSSSSKTIK PKKLPIYELG WILCHLGKKN PSLILGLTFN HYLKNIGLNS
NNNNNKVNSK SQYIQDINCF QILEFLALQP SSYLSIIFQQ HIDKIISNHK SNKNKNNTQF
LKDIKTFLML ITKDDVFLSI GLPIILDKLS PFGINQFDNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN KNNNNNSIKE DNSSEKDIES IKEILEKVLL GNSQVISFYS
KRILLVLYHC CFGDSNDITF SSYSTSTLLQ IKNQTRYNVS IKLLTSIVKD RLEKQLINKL
YSPILNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNQQ QQQQSQEIEN STFINNLNQD
ENITFYLNQI QCNNNNNNNN NNNNNNNNKL IKEKNNIIIK LISLIGMDSI YSSLIILNHI
ISKLKSNQFI QYFYTLVEQF QAVNSNTIEF FINDLFKSID SFSHDDLITL LNNLLELVKI
TPPPSSSSPS NLSIYNETLK CISSNWVVLL KLIKHPNLIE SNKMMSIEIL YHSFNNRYNN
NNNNSQSIQQ LEISNNNNNI KKKEIYPSTL LSDKEMLEIR VLLEKILNLI FKSFKEKNSF
ERLKKFEIYK NLYLLICNGS SVYFSSTIDL ILDSLFSKKT DMIIKLPILC ALSPANTLPP
PNYPANLVNA GSGSGNFGNG DDDDDEYGDD EYGANRNEKE ELYFKQIINP SLPLSQPLIM
LPMQSSLLEI NYERKYYHYK FNDMNNPNHI PFTNKPKNLK KRIENNQSSA IDTTNNNNKN
NEILTYKKQR MKKKKQSIQQ NGNINNEQQQ EEDDNDDADD QNEQDDYEKY NILNNENDLQ
SFIKSLVLYD GGGGSGFNNH GDINDRLQIL TNQFLLRVSS PYLEPSYENY QEILPKQSHY
ERDIFIRNLF QQNPFLYRVL EIISIDGREL TKCLEVIKSL LVNEISYWYQ CRNSYSESPI
KSSHYHTTIL LVKALINAEF IIHPLNLSLE LFDKIKAEEI SYILTSIWNF IKDYQPNPSQ
YQSSSSSSSS SSPPSNNTII PTFKRVFSNC NTTPYSLTLK AIFHNHIKEL CFHYARFFPK
KYY
