ID   INT6A_XENLA             Reviewed;         883 AA.
AC   Q2TAF4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Integrator complex subunit 6-A;
DE            Short=Int6-A;
GN   Name=ints6-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 6 family. {ECO:0000305}.
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DR   EMBL; BC110952; AAI10953.1; -; mRNA.
DR   RefSeq; NP_001089951.1; NM_001096482.1.
DR   AlphaFoldDB; Q2TAF4; -.
DR   SMR; Q2TAF4; -.
DR   BioGRID; 592802; 1.
DR   MaxQB; Q2TAF4; -.
DR   DNASU; 735021; -.
DR   GeneID; 735021; -.
DR   KEGG; xla:735021; -.
DR   CTD; 735021; -.
DR   Xenbase; XB-GENE-6254510; ints6.L.
DR   OrthoDB; 551849at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 735021; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029307; INT_SG_DDX_CT_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..883
FT                   /note="Integrator complex subunit 6-A"
FT                   /id="PRO_0000259546"
FT   DOMAIN          3..227
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
SQ   SEQUENCE   883 AA;  99867 MW;  84A9B85EA5689581 CRC64;
     MPILLFLLDT SASMNQRSHL GTTYLDIAKG AVETFMKLRS RDPASRGDRY MLVTVEEPPY
     GIKAGWKENH ATFMNELKNL QAVGLTTLGQ SLRTAFDLLN LNRLVTGIDN YGQGRNPFFL
     EPSIIIVITD GSKLTTANGV QDELHLPLYS PLPGSELTKE PFRWDQRLFA LVLRLPGASL
     VEQEQPPAVQ FDESPITAMC DVTGGRSYSV TSQRILNQCL ESLVQKVQSG VVIHFEKSGP
     DPPILEDGLT DPVRSVGSQP WHNCHKLIYV RPNPKTGVPL GHWPIPESFW PDQNSPTLPP
     RTSHPVVKFS CTDSEPMIID KLPFDKYELE PSPLTQFILE RKSPHSCWPV FVANSAKYSE
     LGHPFGYLKA STALNCVNLF VLPYNYPVFL PLLDDLFKIH KNKPSLKWRQ LFENYLKTMP
     PYYIGPLKKA LRMMGAPNLM PDSMEYGLSY SVVSYLKKLS QQAKVESDRV IGSIGKKFPQ
     ETGIKVRSGS NALSLALRKD FKQLLQEITG EVPQRPMDLN MKEFAGFQIA LLNKDIKPQT
     FRNAYDVPRT NLLDHLTRMR VNLLRSTRQF LKGQDEDQAH SIPIVQMGNY QEFLKHIPSP
     LRELDYDQPR RLHTFGNPFK LDKKGMMIDE ADEFVSGNQN KHKRTGEPNM QGVPKRRRCM
     SPLLRSRPQS PAVINNHIGG KDPPISVNQV SPDLPKPVAV HKNTDLSNNA TVNEATENHV
     ADHFCDDLLI TKSEPFGTLS SAALEATEGY AAEKDSNFRP NDISDVFLEN TKETGDNESC
     LPNNNAAFTH RKRRLQQCRS YEEANIELKA QILKEIRKPG RKYGIIFTLL KDVQGDLQTR
     LLFLQNVIQE AARFKKRNLI EQLEGFLEEI HRRASQVNHL SSC