ID   INT6B_XENLA             Reviewed;         883 AA.
AC   Q5U4W6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Integrator complex subunit 6-B;
DE            Short=Int6-B;
GN   Name=ints6-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 6 family. {ECO:0000305}.
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DR   EMBL; BC084927; AAH84927.1; -; mRNA.
DR   RefSeq; NP_001088543.1; NM_001095074.1.
DR   AlphaFoldDB; Q5U4W6; -.
DR   SMR; Q5U4W6; -.
DR   PRIDE; Q5U4W6; -.
DR   GeneID; 495417; -.
DR   KEGG; xla:495417; -.
DR   CTD; 495417; -.
DR   Xenbase; XB-GENE-967193; ints6.S.
DR   OrthoDB; 551849at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 495417; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029307; INT_SG_DDX_CT_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..883
FT                   /note="Integrator complex subunit 6-B"
FT                   /id="PRO_0000259547"
FT   DOMAIN          3..227
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
SQ   SEQUENCE   883 AA;  99771 MW;  9C35D9BE7B59AFCA CRC64;
     MPILLFLLDT SASMNQRSHL GTTYLDIAKG AVETFMKLRS RDPASRGDRY MLVTLEELPY
     GIKAGWKENH ATFMNELKNL QAVGLTTLGQ SLRTAFDLLN LNRLVTGIDN YGQGRNPFFL
     EPSIIVAITD GSKLTTANGV QDELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGATA
     VEQEQPTAVQ FDESPITAMC DVTGGRSYSV TSQRILNQCL ESLVQKIQSG VVINFEKSGP
     DPPILEDGLT DPVRSVGSQP WHSCHKLIYV RPNPKTGVPI GHWPIPESFW PDQNSPTLPP
     RTSHPVVKFS CTDSEPLVID KLPFDKYELE PSPLTQFILE RKSPHTCWPV FVPNSAKYCE
     LGHPFGYLKA STALNCVNLF VLPYNYPVLL PLLDDLFKMH KNKPPLKWRQ PFENYLKTMP
     PYYIGPLKKA LRMMGTPNLM PDSMEYGLSY SVVSYLKKLS QQAKVESDRV IGSIGKKYPQ
     ETSIKVRSGS NALSLALRKD FKQLLQEITG EVPQRPMDLN MKEFAGFQIA LLNKDIKPQT
     FRNAYDIPRT NLLDHLTRMR ANLLKSTRQF LKGQDEDQAH SIPIVQMGNY QEYLKHIPSP
     LRELDYDQPR RLHTFGNPFK LDKKGMMIDE ADEFVSGNQN KLKRTGEPNM QGVPKRRRCM
     SPLLHSRPQS PSVINNHISG KDSPVSVNQV LCDLPKPVAV HKNTDMSNNV AINEATENHV
     ADHLCDDLLI TKSESFGTLP NAALEASESY AAGGDSNFSP NDTSDVLLDK TRESGDTESC
     LLNNNTAFVH RKRRLHQCRS YEEANIELKA QILKEIRKPG RKYGIIFTLL KDVQGDLQTR
     LLFLQHVIKE ATRFKKRMLI EQLEGFLEEI HRRTNQVNHL SSC