ID   INT6L_MOUSE             Reviewed;         861 AA.
AC   Q8BND4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Integrator complex subunit 6-like;
DE   AltName: Full=Protein DDX26B;
GN   Name=Ints6l; Synonyms=Ddx26b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CD-1; TISSUE=Neural stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK083942; BAC39076.1; -; mRNA.
DR   EMBL; BC066792; AAH66792.1; -; mRNA.
DR   CCDS; CCDS30145.1; -.
DR   RefSeq; NP_766367.1; NM_172779.4.
DR   AlphaFoldDB; Q8BND4; -.
DR   SMR; Q8BND4; -.
DR   BioGRID; 231796; 1.
DR   STRING; 10090.ENSMUSP00000035379; -.
DR   iPTMnet; Q8BND4; -.
DR   PhosphoSitePlus; Q8BND4; -.
DR   EPD; Q8BND4; -.
DR   jPOST; Q8BND4; -.
DR   MaxQB; Q8BND4; -.
DR   PaxDb; Q8BND4; -.
DR   PeptideAtlas; Q8BND4; -.
DR   PRIDE; Q8BND4; -.
DR   ProteomicsDB; 269070; -.
DR   Antibodypedia; 538; 38 antibodies from 15 providers.
DR   DNASU; 236790; -.
DR   Ensembl; ENSMUST00000039374; ENSMUSP00000035379; ENSMUSG00000035967.
DR   Ensembl; ENSMUST00000132428; ENSMUSP00000138630; ENSMUSG00000035967.
DR   Ensembl; ENSMUST00000186445; ENSMUSP00000139507; ENSMUSG00000035967.
DR   GeneID; 236790; -.
DR   KEGG; mmu:236790; -.
DR   UCSC; uc009tgg.2; mouse.
DR   CTD; 203522; -.
DR   MGI; MGI:2442593; Ints6l.
DR   VEuPathDB; HostDB:ENSMUSG00000035967; -.
DR   eggNOG; KOG3768; Eukaryota.
DR   GeneTree; ENSGT00390000016655; -.
DR   HOGENOM; CLU_006789_0_0_1; -.
DR   InParanoid; Q8BND4; -.
DR   OMA; GIGRSYC; -.
DR   OrthoDB; 551849at2759; -.
DR   PhylomeDB; Q8BND4; -.
DR   TreeFam; TF323386; -.
DR   BioGRID-ORCS; 236790; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Ints6l; mouse.
DR   PRO; PR:Q8BND4; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q8BND4; protein.
DR   Bgee; ENSMUSG00000035967; Expressed in granulocyte and 242 other tissues.
DR   ExpressionAtlas; Q8BND4; baseline and differential.
DR   Genevisible; Q8BND4; MM.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029307; INT_SG_DDX_CT_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..861
FT                   /note="Integrator complex subunit 6-like"
FT                   /id="PRO_0000076216"
FT   DOMAIN          3..227
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   MOD_RES         617
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5JSJ4"
SQ   SEQUENCE   861 AA;  96941 MW;  22D5D4A229FE08CD CRC64;
     MPILLFLIDT SASMNQRTDL GTSYLDIAKG AVELFLKLRA RDPASRGDRY MLVTYDEPPY
     CIKAGWKENH ATFMNELKNL QASGLTTLGQ ALRSSFDLLN LNRLISGIDN YGQGRNPFFL
     EPSILITITD GNKLTSTASV QEELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGVAS
     TEPEQLGSVP SDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVQSG VVINFEKTGP
     DPLPVGEDTL MELCRPSNLF AAQPWHSCHK LIYVRPNSKT GVPVGHWPIP ESFWPEQNLP
     SLPPRTSHPV VRFSCVDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHT CWQVFVTSSS
     KYNELGYPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL FKVHKLKPNL KWRQAFDSYL
     KTLPPYYLIT KLESDQILAS VGKKPPQEIG IKVKNHSACG LPLAHNKSFR KLLKEIIGES
     APRLTELNPK EFAGFQVGLL NKDLKPQTYR NAYDIPRRGL LDQLTRMRSN LLQTRKFIVG
     QDEDSLHSVP VAQMGNYQEY LKMLASPLRE LDPDQPKRLH TFGNPFKQDK KGMMIDEADE
     FVVGPQNKVK RPGEPNSPMS SKRRRSMSLL LRRAQTAPTV TNHVGGKGPL SASWFPSCPS
     LVKHTFGHPD TTVIHDTHEE KMENGQSPPD GFLLKSAPAE FMNVSGESFI SSQLDSLSDD
     FTGLRKDGFI HKPGNNILLG GAKTCSLSVA DQKITMASAL ETVPNSMQIT PAMAQGINAD
     IKHQLMKEVR KFGRKYERIF ILLEEVQGPL ETKKQFVEFT IKEAARFKRR VLIQYLEKVL
     EKIDSHHLLN NVNHINSRSS C