ID   INT6_DANRE              Reviewed;         892 AA.
AC   Q7SYD9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Integrator complex subunit 6;
DE            Short=Int6;
DE   AltName: Full=Protein DDX26B;
GN   Name=ints6; Synonyms=ddx26b; ORFNames=zgc:63527;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UL03}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC054905; AAH54905.1; -; mRNA.
DR   RefSeq; NP_956728.1; NM_200434.1.
DR   AlphaFoldDB; Q7SYD9; -.
DR   SMR; Q7SYD9; -.
DR   STRING; 7955.ENSDARP00000026435; -.
DR   PaxDb; Q7SYD9; -.
DR   PRIDE; Q7SYD9; -.
DR   GeneID; 393406; -.
DR   KEGG; dre:393406; -.
DR   CTD; 203522; -.
DR   ZFIN; ZDB-GENE-040426-1150; ints6l.
DR   eggNOG; KOG3768; Eukaryota.
DR   InParanoid; Q7SYD9; -.
DR   OrthoDB; 551849at2759; -.
DR   PhylomeDB; Q7SYD9; -.
DR   PRO; PR:Q7SYD9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR029307; INT_SG_DDX_CT_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF15300; INT_SG_DDX_CT_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..892
FT                   /note="Integrator complex subunit 6"
FT                   /id="PRO_0000259545"
FT   DOMAIN          3..227
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          665..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          711..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          771..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  99866 MW;  0AB734A802A3A079 CRC64;
     MPILLFLIDT SASMNQRTYL GTTYLDIAKG AVEIFMKLRA RDPASRGDRY MLVTFDDPPY
     GVKAGWKENH ATFMSELKNL QASGLTTLGH ALRAAFDLLN LNRLVSGIDN YGQGRNPFFL
     EPSVIITITD GNKLTHSSGV AEELHLPLNS PLPGSELTKE PFRWDQRLFA LVLRLPGVAV
     PDSEQLGSVP TDESAITQMC EVTGGRSYCV RTQRMLNQCL ESLVQKVLSG VVIHFEKTGP
     DPPVIGEDGL VDPARPLTSF SPQPWHSCHK LIYVRPNPKT GVPVGHWPIS ESFWPDQNSP
     TLPPRSAHPV VRFSCVDCEP MVIDKLPFDK YELEPSPLTQ YILERKSPHM CWQVFVNCSG
     KHSDVAHPFG YLKASTTLTC VNLFVMPYNY PVLLPLLDDL FKVHKLKPNL KWRQSFEMYL
     KSMPPYYLLP LKKALRMMGA PNLISDNMDC GLSYSVISYL KKLSQQAKIE SDRLIVSVGK
     KPPPETGIKV KNHSNALSLA HRRDFKQLLQ GITGEVPLRL IDMNFKEFAG FQIALLNKDL
     KPQAYRNAYD IPRRNLLDQV TRMRSNLLRT TQKLIRGQDD DSLHSIPVGQ MGNYQEYLKM
     MPSPLREIDP DQPKRLHTFG NPFKQDKKGM MIDEADEFVT GPQNKKRGNT GDLNSGTALK
     RRRSMSPLLR RPQTPPIITN HVLGKGPTGT QGQQGIIKPI PLHKGAEGNN VGGTESNGER
     VAGTDAGDCW PGEVDGESGE PAPVEDREDA AAPDGEEEIL ALENCLDDRS PDHTQNCEEL
     SPPGQEGEME VNEGDTPAQG TIVMIPLEGS NAELRTRVIK EVRKPGRNYE AIFRLLEEVK
     GPVSVQRYFI HHAIKEAARF KKRMLIQQLE TALEEIEDRQ MLPAQINNIH SR