INT6_DICDI
ID INT6_DICDI Reviewed; 1107 AA.
AC Q54Z23;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Integrator complex subunit 6 homolog;
GN Name=ints6; ORFNames=DDB_G0277953;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC box-dependent processing. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Integrator subunit 6 family. {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68149.2; -; Genomic_DNA.
DR RefSeq; XP_642029.2; XM_636937.2.
DR AlphaFoldDB; Q54Z23; -.
DR SMR; Q54Z23; -.
DR STRING; 44689.DDB0233765; -.
DR PaxDb; Q54Z23; -.
DR EnsemblProtists; EAL68149; EAL68149; DDB_G0277953.
DR GeneID; 8621240; -.
DR KEGG; ddi:DDB_G0277953; -.
DR dictyBase; DDB_G0277953; ints6.
DR eggNOG; KOG3768; Eukaryota.
DR HOGENOM; CLU_006789_0_0_1; -.
DR InParanoid; Q54Z23; -.
DR OMA; NKVHADI; -.
DR PhylomeDB; Q54Z23; -.
DR PRO; PR:Q54Z23; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome.
FT CHAIN 1..1107
FT /note="Integrator complex subunit 6 homolog"
FT /id="PRO_0000344378"
FT DOMAIN 2..195
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 1041..1103
FT /note="MIF4G"
FT REGION 454..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..860
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 121710 MW; FCB7F27B26A5E210 CRC64;
MLITFVVDTS GSMSQKTTNG MTLLDCSKAA IEHFIKIRSK DASMRNDRFF LITSEENPIT
AVKIGWKDNF NSFIQEVKNL QTKDMSNLGF SLQKSFDFLN QFRVQSSIDN YGQGRNPWFI
EPAIIILLTD GSSLTNSSSI IENFTLPKTQ FHLNSDPTSE PFRWDQRLFS IVLKFGGISS
NKSLPLPMEP AIAPMCDVTG GRCQVATNMK TMIQQVEGLM QKLQGGVVVS FEPLVNQQQA
QAQAQQLLPP PPLSLHKMLY VRQQVGFWPI PEGYYPDITS LSLPMRLAHP VIRYSIIEAD
THIPENFPFD KYELEPCPLT QYLLTNKIQC THVFMMNSLQ VSGQGEPFGC LRLNSAGNSV
NLFVFPYNFP RLWILLEDLT TTFKMMPSQK WKQEFEGYLL SIPPYYINPL RGALKRFCSL
NLIPDNIDSQ FINFINNTIK KIKSQSISKM ESERIINSKQ QQQQQQQFSH QQQFQQFQQK
QAQQYDSSPS SPSSSPSSSS SNTSGIGSSS GSGNLATKKK SFHQILDQGY SSDILSELIQ
QDNETSENSE LSQELSESST TGSSGGGSSS NINILQRNVF DIGRVQLLNQ LDKMKDHIFK
KKIQKDESKH HLPISQMGNY HETIGKRETL RDIDDDKKPN TPLFGNPYRK EKSNQRYMSI
DEADEGGNLT SDGEGKNKLT PNKRRRLSGR GYPSLPTLNS LSNTSTTTST TTTTTTTTPA
TSTNTTITSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSTITSSP PTTSTNPLLQ
PTTASITTST VPIPSTTVSS PITNTSIITT NIHIQPTQIS SPPPLSSSLA INQPTQTSSV
ISSSSSPPPP PPPPPLPIVN NNNVIPSSLV QVTNNNNNIP TVPVNNISPP TSTISSPNNQ
HLLPTPPNIN NTSISTTNVP NISTTTSNES IISQPISPTH KNIAGVVRPF RPNSPPLTID
TLTSSSSSST IPTTTNGSLS THDTPNTSPT LSSINYNNNN NNNNNNNNNN NNNNNNNNNN
NNRKNSIITT TTPNNETNNI IKFVHKEIRR PTKDNHDIII QQLSKLFSIL SDGNLRLKLL
KDTINLAKEY KKSSLISKLI GYIDQIK
