ID   INT7_BOVIN              Reviewed;         962 AA.
AC   Q1RMS6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Integrator complex subunit 7;
DE            Short=Int7;
GN   Name=INTS7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator (INT) complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC       3'-box-dependent processing. The Integrator complex is associated with
CC       the C-terminal domain (CTD) of RNA polymerase II largest subunit
CC       (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role
CC       in DNA damage response (DDR) signaling during the S phase. May be not
CC       involved in the recruitment of cytoplasmic dynein to the nuclear
CC       envelope by different components of the INT complex.
CC       {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with NABP2.
CC       {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9NVH2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9NVH2}. Note=Localizes to sites of DNA damage
CC       in a H2AX-independent manner. {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000305}.
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DR   EMBL; BC114738; AAI14739.1; -; mRNA.
DR   RefSeq; NP_001069512.1; NM_001076044.1.
DR   AlphaFoldDB; Q1RMS6; -.
DR   SMR; Q1RMS6; -.
DR   STRING; 9913.ENSBTAP00000024684; -.
DR   PaxDb; Q1RMS6; -.
DR   PRIDE; Q1RMS6; -.
DR   Ensembl; ENSBTAT00000024684; ENSBTAP00000024684; ENSBTAG00000018548.
DR   GeneID; 534964; -.
DR   KEGG; bta:534964; -.
DR   CTD; 25896; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018548; -.
DR   VGNC; VGNC:30233; INTS7.
DR   eggNOG; KOG1988; Eukaryota.
DR   GeneTree; ENSGT00390000011724; -.
DR   HOGENOM; CLU_013157_0_0_1; -.
DR   InParanoid; Q1RMS6; -.
DR   OMA; FAHIIES; -.
DR   OrthoDB; 1131967at2759; -.
DR   TreeFam; TF106105; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000018548; Expressed in liver and 112 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033060; INTS7.
DR   PANTHER; PTHR13322; PTHR13322; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Cytoplasm; DNA damage; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..962
FT                   /note="Integrator complex subunit 7"
FT                   /id="PRO_0000259548"
FT   MOD_RES         338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVH2"
FT   MOD_RES         809
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVH2"
SQ   SEQUENCE   962 AA;  106771 MW;  6E5A87059DD7A9EE CRC64;
     MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL
     INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA
     ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI
     SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTAYPSTRM VIVSLHTFTL
     LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL
     QTPYDSLKLG MLSVLATLSG TIAVKHYFSI ASGNVGSSPR SSDLVKLAQE CCYHNNRGIA
     AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA
     KGRPHLSQSV VETLLTQLHS AQDTARILMC HCLAAIAMQL PVLGDGMLGD LVELYKVIGR
     SATDKQQELL VSLATVIFVA SQKALSAEVK AVIKQQLESV SNGWTVYRIA RQASRMGNHD
     MARELYQTLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG
     IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND
     LQRCGRISNQ MKLSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL
     ILDPESASFQ EYGSTGAAHA DSEYERRMMS VYNHVLEEVE SLNRKYTPVS YMHTACLCNA
     IISLLKVPLS FQRYFFQKLQ STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK
     PGLFRRIQSV CLNVSSTLQS KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG
     THNITVESSV KDANGIVWKT GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL QQQQQRNAYT
     RF