ID   INT7_CHICK              Reviewed;         961 AA.
AC   Q5ZL91;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Integrator complex subunit 7;
DE            Short=Int7;
GN   Name=INTS7; ORFNames=RCJMB04_7c6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. May play a role in DNA damage response (DDR)
CC       signaling during the S phase. {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000305}.
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DR   EMBL; AJ719843; CAG31502.1; -; mRNA.
DR   RefSeq; NP_001006399.1; NM_001006399.1.
DR   AlphaFoldDB; Q5ZL91; -.
DR   SMR; Q5ZL91; -.
DR   STRING; 9031.ENSGALP00000015986; -.
DR   PaxDb; Q5ZL91; -.
DR   GeneID; 421374; -.
DR   KEGG; gga:421374; -.
DR   CTD; 25896; -.
DR   VEuPathDB; HostDB:geneid_421374; -.
DR   eggNOG; KOG1988; Eukaryota.
DR   InParanoid; Q5ZL91; -.
DR   OrthoDB; 1131967at2759; -.
DR   PhylomeDB; Q5ZL91; -.
DR   PRO; PR:Q5ZL91; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033060; INTS7.
DR   PANTHER; PTHR13322; PTHR13322; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA damage; Nucleus; Reference proteome.
FT   CHAIN           1..961
FT                   /note="Integrator complex subunit 7"
FT                   /id="PRO_0000259551"
FT   REGION          937..961
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   961 AA;  106531 MW;  F8E44B51E2083963 CRC64;
     MAAGGKSFLA DAGYGEQELD ANSALMELDK GLRSGKLGEQ CEAVVRFPRL FQKYPFPILI
     NSAFLKLADV FRVGNNFLRL CVLKVTQQSE KHLEKILNVD EFVKRVFSVI HSNDPVARAI
     TLRMLGSMAS IIPERKNAHH SIRQSLDSHD NVEVEAAIFA AANFSAQSKD FAAGICNKIS
     EMIQGLATPV DLKLKLIPIL QHMHHDASLA SSSRQLLQQL VTSYPSTKMV IVTLHTFTLL
     AASSLVDIPK QVQLLLQYLK NDPRKAVKRL AIQDLKLLAN KIPHTWSREN IQALCESALH
     TPYDSLKLGM LSVLSTLSGT IAIKQYFSSA PGTAATTARS FDLVKLAQEC CYHNNRGIAA
     HGVRILTNIS ASCQEKDLLP LEQDAVFGLE SLLVLCSQDD SPGAQATLKI TLTCMVKLVK
     CRPHLSQSVV ESLLTQLHSA QDAARILMCH CLAAIAMQLP VLADGMLGDL MELYKVIGRS
     TTDKKQELLV SLATVIFVSS QKALSPEIKT VIKQQLENAS NGWTAYRIAR QASRMGNHDM
     ARELYQSLLT QVASEHFYFW LNSLKEFSHA EQCLTGLQED NYSSALSCIA EALKSYHKGI
     ASLTAASTPL NPLSFQCGFV KLRIDLLQAF SQLICTCNSL KTSPPPAIAT TIAMTSGNDL
     QRCGRISNQM KLSMEEFRNL AVRYGDLYQS SFDADSATLR NVELQQQSCL LISHAIEALI
     LDPESANFQE YSSNGAAHVE SEYERRMMSV FNHVLEEVES LNRKYAPVSY LHTACLCSAV
     IALLKVPLSF QRYFFQKLQS TSIKLALSPS PRNPAEPIAV QNNQQLALKV EGVVQHGSKP
     GLFRKIQSVC LNVSSVLQSK SGQDYKIPID NMTNEMEQRV EPHNDYFSTQ FLLNFVILDT
     HNITVESSVI DSNGIVWKTG PKTTIFVKSL EDPYSQQVRL QQQQGQPPSQ QQQQRTAYSR
     F