ID   INT7_DANRE              Reviewed;         964 AA.
AC   Q8JGR7; Q7ZTZ9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Integrator complex subunit 7;
DE            Short=Int7;
GN   Name=ints7; ORFNames=si:dkey-176n7.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION, AND
RP   DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=15716491; DOI=10.1534/genetics.104.039727;
RA   Gross J.M., Perkins B.D., Amsterdam A., Egana A., Darland T., Matsui J.I.,
RA   Sciascia S., Hopkins N., Dowling J.E.;
RT   "Identification of zebrafish insertional mutants with defects in visual
RT   system development and function.";
RL   Genetics 170:245-261(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. May play a role in DNA damage response (DDR)
CC       signaling during the S phase (By similarity). Essential during
CC       embryogenesis for eye development. {ECO:0000250|UniProtKB:Q9NVH2,
CC       ECO:0000269|PubMed:12006978, ECO:0000269|PubMed:15716491}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVH2}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9NVH2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8JGR7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8JGR7-2; Sequence=VSP_021467, VSP_021468;
CC   -!- DISRUPTION PHENOTYPE: Fishes have a defective lens structure and
CC       abnormally shaped jaw and neurocranium. {ECO:0000269|PubMed:12006978,
CC       ECO:0000269|PubMed:15716491}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000305}.
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DR   EMBL; AY099529; AAM28217.1; -; mRNA.
DR   EMBL; BX511163; CAI20733.1; -; Genomic_DNA.
DR   EMBL; BC051607; AAH51607.1; -; mRNA.
DR   RefSeq; NP_775374.1; NM_173267.1. [Q8JGR7-1]
DR   AlphaFoldDB; Q8JGR7; -.
DR   SMR; Q8JGR7; -.
DR   STRING; 7955.ENSDARP00000008647; -.
DR   PaxDb; Q8JGR7; -.
DR   Ensembl; ENSDART00000020703; ENSDARP00000008647; ENSDARG00000019300. [Q8JGR7-1]
DR   Ensembl; ENSDART00000124470; ENSDARP00000126695; ENSDARG00000019300. [Q8JGR7-2]
DR   GeneID; 286776; -.
DR   KEGG; dre:286776; -.
DR   CTD; 25896; -.
DR   ZFIN; ZDB-GENE-021220-6; ints7.
DR   eggNOG; KOG1988; Eukaryota.
DR   GeneTree; ENSGT00390000011724; -.
DR   HOGENOM; CLU_112505_0_0_1; -.
DR   InParanoid; Q8JGR7; -.
DR   OMA; FAHIIES; -.
DR   PhylomeDB; Q8JGR7; -.
DR   TreeFam; TF106105; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q8JGR7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000019300; Expressed in ovary and 28 other tissues.
DR   ExpressionAtlas; Q8JGR7; baseline.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:ZFIN.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033060; INTS7.
DR   PANTHER; PTHR13322; PTHR13322; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chromosome; Developmental protein; DNA damage;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..964
FT                   /note="Integrator complex subunit 7"
FT                   /id="PRO_0000259552"
FT   REGION          937..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         188..213
FT                   /note="DTPVELKLKLIPMLQHMHHDASLASC -> QRNSRSFWCLWQLCYLWPVRRL
FT                   SQLR (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_021467"
FT   VAR_SEQ         214..964
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_021468"
SQ   SEQUENCE   964 AA;  106915 MW;  280310F72EADDAAA CRC64;
     MSLSAARSFL SEAAYGEQEL DANSALMELD KGLRSCKLGE QCEAVVLFPK LFQKYPFPIL
     INSAFLKLAD IFRLGNNFLR LCVLKVTQLS EKHLEKILNV DEFVKRVFSV IHSNDPVARA
     ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAIF AAASFSSHSK DFAAGICNKI
     SEMIQGLDTP VELKLKLIPM LQHMHHDASL ASCSRELLQE LVSSYPSTSM LIVTLHTFTQ
     LATSSLVDIP EQICLLLQYL KEDPRKAVKR LSIQDLKLLA KKAPHLWTRK NIQVLCECAL
     HTPYNSLKLG MLSVLSTLSG TIAIKQYFSP NAGDSSPAPH HTDLVKLAQE CCYHSDLAVA
     AHGITVLTSI AAFCPEKEVI QLEQETVMGM ESLILLCSQD DSKTAQATLK TALTSLVQML
     KTCPHLSQSS VELLLRQLHC ACDPARVLMC QALAAIATQQ PVLVEGMLGD LLELFRVASH
     RTSEKQQELL VSLATVLFVA SQASLSAEVK AVIRQQLENV ANGWTVYQIA RQASRMGCHD
     FSRELYQSLR TRVASEHFYF WLNSLMEFSQ AEQCLSGLED GDYSAAMSAI SEALKSYQKG
     IASLTAASTP LSPLTFQCEF VKLRIDTLQA LSQLICTCNS LKTSPPPAIA TTIALSSGSD
     LQRCGRISTQ MKFSMDEFRS LAARYADLYQ SSFDADYATL RNVELQQQSC LLVSYVIEAL
     IIDPQTASFQ EFGTHGSILA ESEYELRMMA VFNHVLEEVE NLSRKHPPVS YLHTGCLCDT
     VIAILKIPLS FQRYFFQKLQ STSIKLALSP SPRTPNEPIP VQNNQQLTLK VEGVIQHGSS
     PGLFRKIQAV CLKVSSTLQT KPGSDFKIPL ESKTNEIEQK VEPHNDYFST QFLLNFSILG
     THQVSVEASV VDTSGIEWKT GPKNTVSVKS LEDPYSQQLR HQLQQQQQNV PQPAAQRNIS
     TRFQ