ID   INT7_DICDI              Reviewed;        1024 AA.
AC   Q54PL2;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Integrator complex subunit 7 homolog;
GN   Name=ints7; ORFNames=DDB_G0284483;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000066; EAL65168.1; -; Genomic_DNA.
DR   RefSeq; XP_638520.1; XM_633428.1.
DR   AlphaFoldDB; Q54PL2; -.
DR   SMR; Q54PL2; -.
DR   STRING; 44689.DDB0234098; -.
DR   PaxDb; Q54PL2; -.
DR   PRIDE; Q54PL2; -.
DR   EnsemblProtists; EAL65168; EAL65168; DDB_G0284483.
DR   GeneID; 8624613; -.
DR   KEGG; ddi:DDB_G0284483; -.
DR   dictyBase; DDB_G0284483; ints7.
DR   eggNOG; KOG1988; Eukaryota.
DR   HOGENOM; CLU_295513_0_0_1; -.
DR   InParanoid; Q54PL2; -.
DR   OMA; CGTILME; -.
DR   PRO; PR:Q54PL2; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033060; INTS7.
DR   PANTHER; PTHR13322; PTHR13322; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1024
FT                   /note="Integrator complex subunit 7 homolog"
FT                   /id="PRO_0000344379"
FT   REGION          1..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1024 AA;  116051 MW;  C72F1503FC5A79E2 CRC64;
     MSKYKNSSLL NDQGGVRQPS LSNGSSVLGI SNQLPPNSLF HLFSTNNQQS TTTPTTVTIQ
     PPSSSISTPS PTTNNTVSGG GGIQTAGSST SSASSVVGGG GGTTTPTNSN IVVIESNKED
     DKECGTILME INKGIRSGNL GEQIESILFF SHLIKFHPSP LIVNSVITRL SDIFRTTSNT
     VKYRILKVFQ ECSSEIHKVS NIEEVLKRIH SVILSNDPIA RSLSLRVLGS VPHLIADKLY
     IHHSIRTCMQ SHDQVELEAT IFIMDKLCEI SPLFSDSIIE KIHTVIQNVE TPPITKLKYT
     RLFRHMHHSH SIATQSKEML VGLLDLYPSV GFVSVILDTL TNLSLKHILY IDDHIKFLKN
     YGFSDSRVVV KVIALKCLQK LAITSPHSQF PIIEIFNIIK ETPSKSYREI KYNALLLLSI
     LSQSQYTKIL ELNQANDNDL IDILYQYSLD YDFKLSELSI QTLVNIIVES TDNNNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNKLIESILN QTVNNICVIL KTQFTTSTNN NTNINENKST
     LNKTSVFLKS IIRLIKKDPK PLKSITTTII SLLNEIPYSI LKSLFHCLSM CIPMNKSVLN
     QNGWFKLILD YLNNLIIKEN SVQLINNNFN NNNNNNNNSN NNNNNIINRN NNGISNGINK
     QDCKYSIPMS IFMCIFKTFD ENNQKIQEIT EQLLPLIQYI LENPKPDQLW SCYNLAQLSQ
     RHGFHKIAMV IYSTLIHKVE SECNYLWLKG LLSIATLENE ISIYSITTNK NNTNNNNNNN
     NSKILNQLSN YHTSIVSLKA SSQQERSLQF QEDFILLHEK YLFNILNLKS FLLECNDDGN
     NNNNNNNNNN NNNNNNNNNN NNNNNEILLK RFLSKSLIFR QLEQKYQLLL NIQSKSINHT
     VPLDTKQILE SFIFSCNLIV KLIDLIVINK NNNNNNNINA NGINHQQEQR YQQHQQSQNQ
     ELINYFPLFK FCEFIQKKLN QQHSIPSSSS SSSSTTNPIS FLDQVLNGLI KIPMVYPSSF
     YFKF