ID   INT8_DICDI              Reviewed;         198 AA.
AC   Q54VK3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Integrator complex subunit 8-like protein;
GN   ORFNames=DDB_G0280285;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May be a component of the Integrator complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000035; EAL67369.1; -; Genomic_DNA.
DR   RefSeq; XP_641352.1; XM_636260.1.
DR   AlphaFoldDB; Q54VK3; -.
DR   SMR; Q54VK3; -.
DR   STRING; 44689.DDB0234102; -.
DR   PaxDb; Q54VK3; -.
DR   EnsemblProtists; EAL67369; EAL67369; DDB_G0280285.
DR   GeneID; 8622486; -.
DR   KEGG; ddi:DDB_G0280285; -.
DR   dictyBase; DDB_G0280285; -.
DR   eggNOG; ENOG502RCDK; Eukaryota.
DR   HOGENOM; CLU_1380336_0_0_1; -.
DR   InParanoid; Q54VK3; -.
DR   OMA; YFQYIWE; -.
DR   PhylomeDB; Q54VK3; -.
DR   PRO; PR:Q54VK3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   InterPro; IPR038751; Int8.
DR   PANTHER; PTHR13350; PTHR13350; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..198
FT                   /note="Integrator complex subunit 8-like protein"
FT                   /id="PRO_0000344380"
SQ   SEQUENCE   198 AA;  23702 MW;  550697202FA01499 CRC64;
     MNKIFGVKID SQQKKRQQSN KNLTVFNNGR YLIYIGDIHF DRKFHREALR YYLLGCGLET
     AFYSDPVKTS VTNSKYLTFL SRRIFDCFYF LRAPMQAIVV SQFFGNLNQT CLVSFKIIQE
     EYYQLDTNYF QYIWELPLLE ILLTTFTKQK DLKKIYLINQ IISNPIINEN NHPDIRKNFI
     KNTKHNFWKA ISSNYLLQ