INT8_HUMAN
ID INT8_HUMAN Reviewed; 995 AA.
AC Q75QN2; B2RN92; Q5RKZ3; Q6P1R5; Q7Z314; Q9NVS6; Q9NWY7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Integrator complex subunit 8;
DE Short=Int8;
DE AltName: Full=Protein kaonashi-1;
GN Name=INTS8; Synonyms=C8orf52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Atsushi S., Asakawa S., Shimizu N.;
RT "Novel gene with no significant domain.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-995 (ISOFORM 2).
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-995 (ISOFORM 1).
RC TISSUE=Carcinoma, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE INTEGRATOR
RP COMPLEX.
RX PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA Shiekhattar R.;
RT "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT associates with the C-terminal repeat of RNA polymerase II.";
RL Cell 123:265-276(2005).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [8]
RP VARIANTS NEDCHS GLY-298 AND 973-GLU--LEU-975 DEL, CHARACTERIZATION OF
RP VARIANTS NEDCHS GLY-298 AND 973-GLU--LEU-975 DEL, DEVELOPMENTAL STAGE, AND
RP FUNCTION.
RX PubMed=28542170; DOI=10.1371/journal.pgen.1006809;
RA Oegema R., Baillat D., Schot R., van Unen L.M., Brooks A., Kia S.K.,
RA Hoogeboom A.J.M., Xia Z., Li W., Cesaroni M., Lequin M.H.,
RA van Slegtenhorst M., Dobyns W.B., de Coo I.F.M., Verheijen F.W., Kremer A.,
RA van der Spek P.J., Heijsman D., Wagner E.J., Fornerod M., Mancini G.M.S.;
RT "Human mutations in integrator complex subunits link transcriptome
RT integrity to brain development.";
RL PLoS Genet. 13:e1006809-e1006809(2017).
CC -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC box-dependent processing. The Integrator complex is associated with the
CC C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A)
CC and is recruited to the U1 and U2 snRNAs genes.
CC {ECO:0000269|PubMed:28542170}.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
CC {ECO:0000269|PubMed:16239144}.
CC -!- INTERACTION:
CC Q75QN2; Q6P9B9: INTS5; NbExp=3; IntAct=EBI-2340089, EBI-7600112;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q75QN2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q75QN2-2; Sequence=VSP_021469;
CC -!- DEVELOPMENTAL STAGE: Highly expressed in the brain in the ventricular
CC and subventricular zones, caudal and lateral ganglionic eminences and
CC cerebellar primordium at 16-21 postconceptional week.
CC {ECO:0000269|PubMed:28542170}.
CC -!- DISEASE: Neurodevelopmental disorder with cerebellar hypoplasia and
CC spasticity (NEDCHS) [MIM:618572]: An autosomal recessive
CC neurodevelopmental disorder characterized by global developmental
CC delay, profound intellectual disability, seizures, absent speech,
CC spasticity, facial and limb dysmorphism, and subtle structural brain
CC abnormalities including cerebellar hypoplasia.
CC {ECO:0000269|PubMed:28542170}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the Integrator subunit 8 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH50536.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA91238.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA91671.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB161944; BAD10863.1; -; mRNA.
DR EMBL; CH471060; EAW91726.1; -; Genomic_DNA.
DR EMBL; BC050536; AAH50536.1; ALT_FRAME; mRNA.
DR EMBL; BC064915; AAH64915.1; -; mRNA.
DR EMBL; BC136754; AAI36755.1; -; mRNA.
DR EMBL; BX538203; CAD98067.1; -; mRNA.
DR EMBL; AK000537; BAA91238.1; ALT_INIT; mRNA.
DR EMBL; AK001403; BAA91671.1; ALT_INIT; mRNA.
DR EMBL; BK005731; DAA05731.1; -; mRNA.
DR CCDS; CCDS34925.1; -. [Q75QN2-1]
DR RefSeq; NP_060334.2; NM_017864.3. [Q75QN2-1]
DR RefSeq; XP_016869108.1; XM_017013619.1.
DR PDB; 7CUN; EM; 3.50 A; H=1-995.
DR PDB; 7PKS; EM; 3.60 A; h=1-995.
DR PDBsum; 7CUN; -.
DR PDBsum; 7PKS; -.
DR AlphaFoldDB; Q75QN2; -.
DR SMR; Q75QN2; -.
DR BioGRID; 120788; 46.
DR ComplexPortal; CPX-6441; Integrator complex.
DR CORUM; Q75QN2; -.
DR IntAct; Q75QN2; 12.
DR MINT; Q75QN2; -.
DR STRING; 9606.ENSP00000430338; -.
DR iPTMnet; Q75QN2; -.
DR PhosphoSitePlus; Q75QN2; -.
DR BioMuta; INTS8; -.
DR DMDM; 74712892; -.
DR EPD; Q75QN2; -.
DR jPOST; Q75QN2; -.
DR MassIVE; Q75QN2; -.
DR MaxQB; Q75QN2; -.
DR PaxDb; Q75QN2; -.
DR PeptideAtlas; Q75QN2; -.
DR PRIDE; Q75QN2; -.
DR ProteomicsDB; 68647; -. [Q75QN2-1]
DR ProteomicsDB; 68648; -. [Q75QN2-2]
DR Antibodypedia; 25892; 47 antibodies from 17 providers.
DR DNASU; 55656; -.
DR Ensembl; ENST00000523731.6; ENSP00000430338.1; ENSG00000164941.14. [Q75QN2-1]
DR GeneID; 55656; -.
DR KEGG; hsa:55656; -.
DR MANE-Select; ENST00000523731.6; ENSP00000430338.1; NM_017864.4; NP_060334.2.
DR UCSC; uc003yhb.5; human. [Q75QN2-1]
DR CTD; 55656; -.
DR DisGeNET; 55656; -.
DR GeneCards; INTS8; -.
DR HGNC; HGNC:26048; INTS8.
DR HPA; ENSG00000164941; Low tissue specificity.
DR MalaCards; INTS8; -.
DR MIM; 611351; gene.
DR MIM; 618572; phenotype.
DR neXtProt; NX_Q75QN2; -.
DR OpenTargets; ENSG00000164941; -.
DR PharmGKB; PA142672371; -.
DR VEuPathDB; HostDB:ENSG00000164941; -.
DR eggNOG; ENOG502QQS8; Eukaryota.
DR GeneTree; ENSGT00390000007597; -.
DR HOGENOM; CLU_012129_0_0_1; -.
DR InParanoid; Q75QN2; -.
DR OMA; YYSCIWD; -.
DR OrthoDB; 461829at2759; -.
DR PhylomeDB; Q75QN2; -.
DR TreeFam; TF324241; -.
DR PathwayCommons; Q75QN2; -.
DR Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR SignaLink; Q75QN2; -.
DR SIGNOR; Q75QN2; -.
DR BioGRID-ORCS; 55656; 685 hits in 1082 CRISPR screens.
DR ChiTaRS; INTS8; human.
DR GeneWiki; INTS8; -.
DR GenomeRNAi; 55656; -.
DR Pharos; Q75QN2; Tdark.
DR PRO; PR:Q75QN2; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q75QN2; protein.
DR Bgee; ENSG00000164941; Expressed in secondary oocyte and 198 other tissues.
DR ExpressionAtlas; Q75QN2; baseline and differential.
DR Genevisible; Q75QN2; HS.
DR GO; GO:0032039; C:integrator complex; IDA:HGNC-UCL.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IC:ComplexPortal.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0016180; P:snRNA processing; IDA:HGNC-UCL.
DR InterPro; IPR038751; Int8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13350; PTHR13350; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disease variant;
KW Intellectual disability; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..995
FT /note="Integrator complex subunit 8"
FT /id="PRO_0000259553"
FT REPEAT 250..288
FT /note="TPR 1"
FT REPEAT 320..356
FT /note="TPR 2"
FT REPEAT 570..603
FT /note="TPR 3"
FT REPEAT 833..866
FT /note="TPR 4"
FT MOD_RES 18
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17081983"
FT VAR_SEQ 879..895
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_021469"
FT VARIANT 298
FT /note="D -> G (in NEDCHS; occurs in a splice site resulting
FT in altered splicing and probable nonsense-mediated mRNA
FT decay; dbSNP:rs1586479593)"
FT /evidence="ECO:0000269|PubMed:28542170"
FT /id="VAR_083358"
FT VARIANT 973..975
FT /note="Missing (in NEDCHS; alters the assembly of the
FT Integrator complex)"
FT /evidence="ECO:0000269|PubMed:28542170"
FT /id="VAR_083359"
FT CONFLICT 778
FT /note="V -> A (in Ref. 5; BAA91238)"
FT /evidence="ECO:0000305"
FT CONFLICT 832
FT /note="N -> S (in Ref. 4; CAD98067)"
FT /evidence="ECO:0000305"
FT HELIX 47..53
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 61..69
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 71..77
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 79..82
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 83..96
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 110..118
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 137..156
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 171..191
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 192..194
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 195..206
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 213..232
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 235..237
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 242..258
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 262..266
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 269..282
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 327..336
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 340..347
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 356..371
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 372..374
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 378..395
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 401..407
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 412..422
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 424..427
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 435..445
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 446..448
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 453..459
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 462..464
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 467..469
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 470..472
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 474..484
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 503..505
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 506..517
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 522..535
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 552..558
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 564..582
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 586..600
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 605..625
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 637..648
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 657..669
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 682..684
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 689..701
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 712..724
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 736..738
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 740..744
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 750..752
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 756..762
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 767..781
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 782..784
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 786..788
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 806..808
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 811..828
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 833..845
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 849..863
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 865..867
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 873..875
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 878..889
FT /evidence="ECO:0007829|PDB:7CUN"
FT TURN 890..892
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 894..900
FT /evidence="ECO:0007829|PDB:7CUN"
FT STRAND 903..906
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 909..916
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 925..927
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 929..931
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 935..947
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 951..961
FT /evidence="ECO:0007829|PDB:7CUN"
FT HELIX 975..993
FT /evidence="ECO:0007829|PDB:7CUN"
SQ SEQUENCE 995 AA; 113088 MW; 24D06E11821BD4D5 CRC64;
MSAEAADREA ATSSRPCTPP QTCWFEFLLE ESLLEKHLRK PCPDPAPVQL IVQFLEQASK
PSVNEQNQVQ PPPDNKRNRI LKLLALKVAA HLKWDLDILE KSLSVPVLNM LLNELLCISK
VPPGTKHVDM DLATLPPTTA MAVLLYNRWA IRTIVQSSFP VKQAKPGPPQ LSVMNQMQQE
KELTENILKV LKEQAADSIL VLEAALKLNK DLYVHTMRTL DLLAMEPGMV NGETESSTAG
LKVKTEEMQC QVCYDLGAAY FQQGSTNSAV YENAREKFFR TKELIAEIGS LSLHCTIDEK
RLAGYCQACD VLVPSSDSTS QQLTPYSQVH ICLRSGNYQE VIQIFIEDNL TLSLPVQFRQ
SVLRELFKKA QQGNEALDEI CFKVCACNTV RDILEGRTIS VQFNQLFLRP NKEKIDFLLE
VCSRSVNLEK ASESLKGNMA AFLKNVCLGL EDLQYVFMIS SHELFITLLK DEERKLLVDQ
MRKRSPRVNL CIKPVTSFYD IPASASVNIG QLEHQLILSV DPWRIRQILI ELHGMTSERQ
FWTVSNKWEV PSVYSGVILG IKDNLTRDLV YILMAKGLHC STVKDFSHAK QLFAACLELV
TEFSPKLRQV MLNEMLLLDI HTHEAGTGQA GERPPSDLIS RVRGYLEMRL PDIPLRQVIA
EECVAFMLNW RENEYLTLQV PAFLLQSNPY VKLGQLLAAT CKELPGPKES RRTAKDLWEV
VVQICSVSSQ HKRGNDGRVS LIKQRESTLG IMYRSELLSF IKKLREPLVL TIILSLFVKL
HNVREDIVND ITAEHISIWP SSIPNLQSVD FEAVAITVKE LVRYTLSINP NNHSWLIIQA
DIYFATNQYS AALHYYLQAG AVCSDFFNKA VPPDVYTDQV IKRMIKCCSL LNCHTQVAIL
CQFLREIDYK TAFKSLQEQN SHDAMDSYYD YIWDVTILEY LTYLHHKRGE TDKRQIAIKA
IGQTELNASN PEEVLQLAAQ RRKKKFLQAM AKLYF
