ID   INT8_XENLA              Reviewed;         991 AA.
AC   Q4V847;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Integrator complex subunit 8;
DE            Short=Int8;
GN   Name=ints8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250|UniProtKB:Q75QN2}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q75QN2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q75QN2}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097549; AAH97549.1; -; mRNA.
DR   RefSeq; NP_001089452.1; NM_001095983.1.
DR   AlphaFoldDB; Q4V847; -.
DR   SMR; Q4V847; -.
DR   BioGRID; 592283; 1.
DR   PRIDE; Q4V847; -.
DR   GeneID; 734502; -.
DR   KEGG; xla:734502; -.
DR   CTD; 734502; -.
DR   Xenbase; XB-GENE-980135; ints8.S.
DR   OrthoDB; 461829at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 734502; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IEA:InterPro.
DR   InterPro; IPR038751; Int8.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13350; PTHR13350; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..991
FT                   /note="Integrator complex subunit 8"
FT                   /id="PRO_0000259555"
FT   REPEAT          250..288
FT                   /note="TPR 1"
FT   REPEAT          319..355
FT                   /note="TPR 2"
FT   REPEAT          569..602
FT                   /note="TPR 3"
FT   REPEAT          829..862
FT                   /note="TPR 4"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   991 AA;  112618 MW;  C9311DA3988D24C6 CRC64;
     MSAEAADREA ATSSRPCTPP QTSWFEFLLD DSLLEKHLQK PHSDPPPVQL IVQFLEQASK
     PTLNEQNQVQ PPTDNKRNRT LKLLALKVAA HLKWNLDVLE KSLSVPVLNM LLNELLCASK
     VPPGTKHVDL DLSTLPPTTV MAVTLYNRWA IRTIVQSGFP VKPVKQGPQQ PNVMNQIQQE
     KELTENILKV LKEQAEDSIT VLEGALQLKR DFYVHTMRTL DLLAVEPGMV NGETENSTAG
     FKISSDEMQC QGCYDLGAVY FLQGPTNPSC YEKARDHFFR TKQLVSKIGA ASDHYAIDEK
     RLAGYCQACG VLAPSNVVSQ PATPYSQIHN FMKTNNYQGI LKIFLEDHLN NSLPDQFRQS
     VLRELFQKSQ QGNGALAELC FKVCACNTVY DILHGQPVTV QFHQLFMKPS KEKIDFLLEV
     CSRSLMSDQA SEASKRKIAT FLKNLCLEIE DLQLVFMISS HELFMKMLTD EESKMVVEHL
     RKKTSRVSMC TKPITSFYDI PASASVNIGQ LEHQLILTVD PWRIRQILIE LHGMTSDRQY
     WKVSSKWEVP TIYSGSILGI KDNLTRDLVY ILLAKGLHCS AIKDYPRAKQ LLSACLELVT
     EFSPKLRQVM LNEMLLLDIY TYEAVSAQER PPPELISRVR GYLEMRIPDI PLRQVVAEEC
     VAFLLNWREN ECLTLQVPAS LVQSNPYVKL GQLLAATCKE LPGPDSRRTA KDLWEVVVQI
     CSVSNQHKRN NDGRVCLIKN RDSTMGIMYR NELVSFIKKL REPLVLTTLL SLFVKLHNLR
     EDIVNDITAE HISIWPSCIP NLQAVDFDAV AVTVKELVSY ALTINSNSHS WLTIQADIYF
     ATNEYSAALN YYLQAGAVCS DFFTKQVPPE VYTDQVIKRM IKCCSMLNCH TQVAILCQFL
     REIDYKTAFK ALQEQNSHDG MDSYYDYIWD VTILEYLTYL HHKRGETDKR QIAIKAIGQT
     ELNASNPDEV LQLAAQRRKK KFLQSMAKLY F