ID   INT9_BOVIN              Reviewed;         658 AA.
AC   Q2KJA6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Integrator complex subunit 9;
DE            Short=Int9;
GN   Name=INTS9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator (INT) complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC       3'-box-dependent processing. The Integrator complex is associated with
CC       the C-terminal domain (CTD) of RNA polymerase II largest subunit
CC       (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates
CC       recruitment of cytoplasmic dynein to the nuclear envelope, probably as
CC       component of the INT complex. {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts
CC       with ESRRB, ESRRB is probably not a core component of the multiprotein
CC       complex Integrator and this association is a bridge for the interaction
CC       with the multiprotein complex Integrator; attracts the transcriptional
CC       machinery (By similarity). {ECO:0000250|UniProtKB:Q8K114,
CC       ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- MISCELLANEOUS: Although strongly related to RNA-specific endonuclease
CC       proteins, it lacks the HXHXDH motif that binds zinc and participates in
CC       the catalytic center. Its function as endonuclease is therefore unsure.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC105437; AAI05438.1; -; mRNA.
DR   RefSeq; NP_001039828.1; NM_001046363.1.
DR   AlphaFoldDB; Q2KJA6; -.
DR   SMR; Q2KJA6; -.
DR   STRING; 9913.ENSBTAP00000046018; -.
DR   PaxDb; Q2KJA6; -.
DR   PRIDE; Q2KJA6; -.
DR   GeneID; 533964; -.
DR   KEGG; bta:533964; -.
DR   CTD; 55756; -.
DR   eggNOG; KOG1138; Eukaryota.
DR   InParanoid; Q2KJA6; -.
DR   OrthoDB; 617493at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation.
FT   CHAIN           1..658
FT                   /note="Integrator complex subunit 9"
FT                   /id="PRO_0000259556"
FT   REGION          548..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        58
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NV88"
SQ   SEQUENCE   658 AA;  73837 MW;  991EFA9DEE13C57E CRC64;
     MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS NLPGWSLKDG
     NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL ISNYHCMMAL PYITEHTGFT
     GTVYATEPTV QIGRLLMEEL VNFIERVPKA QSASLWKNKD IQRLLPSPLK DAVEVSTWRR
     CYTMQEVNSA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS
     SLLTTHPQPM DQASLKNSDV LILTGLTQIP TANPDSMVGE FCSNLALTVR NGGNVLVPCY
     PSGVIYDLLE CLYQYIDSAG LSSIPFYFIS PVANSSLEFS QIFAEWLCHN KQTKVYLPEP
     PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL RFGDVVHFME LWGKSSLNTV
     IFTEPDFSYL EALAPYQPLA MKCIYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPTP
     AQSHRMDLMV DCQPPAMSYR RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV
     SAVLHTKDNK HVLQPPPRPT QPTGGKKRKR ASDDIPDCKV LKPLLSGSIP VDQFVQTLEK
     HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDDD EVLRVRLRDL VLKFLQKF