ID   INT9_CHICK              Reviewed;         658 AA.
AC   Q5ZKK2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Integrator complex subunit 9;
DE            Short=Int9;
GN   Name=INTS9; ORFNames=RCJMB04_10e20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator.
CC       {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NV88}.
CC   -!- MISCELLANEOUS: Although strongly related to RNA-specific endonuclease
CC       proteins, it lacks the HXHXDH motif that binds zinc and participates in
CC       the catalytic center. Its function as endonuclease is therefore unsure.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ720082; CAG31741.1; -; mRNA.
DR   RefSeq; NP_001026271.1; NM_001031100.1.
DR   AlphaFoldDB; Q5ZKK2; -.
DR   SMR; Q5ZKK2; -.
DR   STRING; 9031.ENSGALP00000042736; -.
DR   PaxDb; Q5ZKK2; -.
DR   Ensembl; ENSGALT00000026848; ENSGALP00000026797; ENSGALG00000016631.
DR   GeneID; 422023; -.
DR   KEGG; gga:422023; -.
DR   CTD; 55756; -.
DR   VEuPathDB; HostDB:geneid_422023; -.
DR   eggNOG; KOG1138; Eukaryota.
DR   GeneTree; ENSGT00390000001445; -.
DR   HOGENOM; CLU_023159_1_0_1; -.
DR   InParanoid; Q5ZKK2; -.
DR   OMA; CADSIKD; -.
DR   OrthoDB; 617493at2759; -.
DR   PhylomeDB; Q5ZKK2; -.
DR   TreeFam; TF314100; -.
DR   Reactome; R-GGA-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q5ZKK2; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000016631; Expressed in testis and 13 other tissues.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR027074; Integrator_9su.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR46094; PTHR46094; 1.
DR   Pfam; PF16661; Lactamase_B_6; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..658
FT                   /note="Integrator complex subunit 9"
FT                   /id="PRO_0000259560"
FT   REGION          550..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  73763 MW;  A6B83632B1B3704D CRC64;
     MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS KLPGLVLKDG
     STFLDKELKE CSGHVFVDSV PEFCLPETEL LDLSTVDVIL ISNYHCMMAL PYITEYTGFT
     GTVYATEPTV QIGRLLMEEL VNSIERVPKA QSASTWKNKE VQRLLPAPLK DAVEVSMWRK
     CYTMPEVNAA LSKIQLVGYS QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS
     SLLTTHPQPM DQASLKNSDV LILTGLTQIP TANPDGMVGE FCSNLAMTVR NGGNVLVPCY
     PSGVIYDLLE CLYQYIDSAG LSNVPFYFIS PVANSSLEFS QIFAEWLCHN KQTKVYLPEP
     PFPHAELIQT NKLKHYPSIH GDFSNDFKQP CVIFTGHPSL RFGDVVHFME LWGKSSLNTV
     IFTEPDFSYL DALAPYQPLA MKCVYCPIDT RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP
     SQSHRTDLMI DCQPPPMSYR RAEVLTLPYK RRYEKIEIMP ELADSLVPLE IKPGISLATV
     SAMLHTKDNK HVLQLPPKPP QPPTSKKRKR VSDDVPECKP LKPLLSGSIP VDQFVQTLEK
     HGFSDVKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EPLRVKLRDL VLKFLQKF